Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery.
Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery.
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DOI：
10.1039/c2ra22293k
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发表时间：
2013-02-28
期刊：
影响因子：
3.9
通讯作者：
Mohapatra S
中科院分区：
文献类型：
--
作者：
Dixit S;Das M;Alwarappan S;Goicochea NL;Howell M;Mohapatra S;Mohapatra S
我们将氧化钆（Gd2O3）纳米颗粒封装在磷脂胶束中，作为一种新型的低细胞毒性T1加权MRI成像造影剂（MGdNPs），也可以提供小分子，如DNA质粒。MGdNP显示出相对良好的MRI弛豫率值、可忽略的细胞毒性、优异的细胞摄取和DNA质粒的体内表达。小鼠中的生物分布研究表明，MGdNP的鼻内和腹膜内施用可以有效地靶向特定器官。
We encapsulated gadolinium oxide (Gd2O3) nanoparticles within phospholipid micelles as a novel low cytotoxic T1-weighted MRI imaging contrast agent (MGdNPs) that can also deliver small molecules such as DNA plasmids. MGdNPs show relatively good MRI relaxivity values, negligible cytotoxicity, excellent cellular uptake and expression of DNA plasmids in vivo. Biodistribution studies in mice show that intranasal and intraperitoneal administration of MGdNPs can effectively target specific organs.