Lipidome and transcriptome profiling of pneumolysin intoxication identifies networks involved in statin-conferred protection of airway epithelial cells.
Lipidome and transcriptome profiling of pneumolysin intoxication identifies networks involved in statin-conferred protection of airway epithelial cells.
复制标题
肺炎球菌溶血素中毒的脂质组和转录组分析确定了参与他汀类药物对气道上皮细胞的保护的网络。
DOI：
10.1038/srep10624
复制
发表时间：
2015
影响因子：
4.6
通讯作者：
Kao,Cheng-Yuan
中科院分区：
文献类型：
--
作者：
Statt,Sarah;Ruan,Jhen-Wei;Huang,Chih-Ting;Wu,Reen;Kao,Cheng-Yuan
Pneumonia remains one of the leading causes of death in both adults and children worldwide. Despite the adoption of a wide variety of therapeutics, the mortality from community-acquired pneumonia has remained relatively constant. Although viral and fungal acute airway infections can result in pneumonia, bacteria are the most common cause of community-acquired pneumonia, withStreptococcus pneumoniaeisolated in nearly 50% of cases. Pneumolysin is a cholesterol-dependent cytolysin or pore-forming toxin produced byStreptococcus pneumoniaand has been shown to play a critical role in bacterial pathogenesis. Airway epithelium is the initial site of many bacterial contacts and its barrier and mucosal immunity functions are central to infectious lung diseases. In our studies, we have shown that the prior exposure to statins confers significant resistance of airway epithelial cells to the cytotoxicity of pneumolysin. We decided to take this study one step further, assessing changes in both the transcriptome and lipidome of human airway epithelial cells exposed to toxin, statin or both. Our current work provides the first global view in human airway epithelial cells of both the transcriptome and the lipid interactions that result in cellular protection from pneumolysin.
