A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus
A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus
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褪黑激素受体 1B 的功能多态性 rs10830963 与妊娠糖尿病风险相关
DOI：
10.1042/bsr20190744
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发表时间：
2019-12-20
影响因子：
4
通讯作者：
Yu, Xiang-yuan
中科院分区：
文献类型：
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作者：
Huang, Bo;Wang, Yu-kun;Yu, Xiang-yuan
摘要褪黑激素受体1B（MTNR 1B）基因多态性rs 10830963 C>G与妊娠期糖尿病（GDM）的发病风险相关，但研究结果不一致。为了阐明多态性对GDM风险的影响，因此进行了荟萃分析。合并OR及其相应的95%CI用于估计相关性的强度。共纳入14个合格的研究，5033例GDM患者和5614例对照。结果表明，变异G等位基因与GDM风险增加显著相关（CG vs. CC：OR = 1.25，95% CI = 1.11−1.40，P < 0.001; GG vs. CC：OR = 1.78，95% CI = 1.45−2.19，P < 0.001; G vs. C：OR = 1.33，95%CI = 1.21 - 1.47，P < 0.001）。在按种族进行的分层分析中，在亚洲人中也发现了类似的结果（CG vs. CC：OR = 1.15，95%CI = 1.02 - 1.28，P = 0.020; GG vs. CC：OR = 1.52，95%CI = 1.23 - 1.89，P < 0.001; G vs. C：OR = 1.23，95% CI = 1.10 - 1.37，P < 0.001）和白人（CG与CC：OR = 1.40，95% CI = 1.16−1.70，P < 0.001; GG与CC：OR = 2.21，95% CI = 1.54−3.17，P < 0.001; G与C：OR = 1.47，95%CI = 1.24 - 1.73，P < 0.001）。FPRP和TSA分析证实了rs 10830963 G等位基因增加GDM的风险，并需要进一步的功能实验研究来探索和阐明潜在的机制。
Abstract The melatonin receptor 1B (MTNR1B) polymorphism rs10830963 C>G has been reported to be associated with the risk of gestational diabetes mellitus (GDM) with inconsistent results. To clarify the effect of the polymorphism on the risk of GDM, a meta-analysis therefore was performed. Pooled OR with its corresponding 95%CI was used to estimate the strength of the association. Totally 14 eligible studies with a number of 5033 GDM patients and 5614 controls were included in this meta-analysis. Results indicated that the variant G allele was significantly associated with an increased GDM risk (CG vs. CC: OR = 1.25, 95% CI = 1.11−1.40, P < 0.001; GG vs. CC: OR = 1.78, 95% CI = 1.45−2.19, P < 0.001; G vs. C: OR = 1.33, 95% CI = 1.21−1.47, P < 0.001). In the stratified analysis by ethnicity, similar results were found in Asians (CG vs. CC: OR = 1.15, 95%CI = 1.02−1.28, P = 0.020; GG vs. CC: OR = 1.52, 95% CI = 1.23−1.89, P < 0.001; G vs. C: OR = 1.23, 95% CI = 1.10−1.37, P < 0.001) and in Caucasians (CG vs. CC: OR = 1.40, 95% CI = 1.16−1.70, P < 0.001; GG vs. CC: OR = 2.21, 95% CI = 1.54−3.17, P < 0.001; G vs. C: OR = 1.47, 95% CI = 1.24−1.73, P < 0.001). FPRP and TSA analyses confirmed findings support that the rs10830963 G allele increases the risk of GDM, and further functional experimental studies are warranted to explore and clarify the potential mechanism.