Decreased Serum Lipid Levels and Ratios Correlate with Low Prevalence of Coronary Heart Disease in Patients with Parkinson's Disease
Decreased Serum Lipid Levels and Ratios Correlate with Low Prevalence of Coronary Heart Disease in Patients with Parkinson's Disease
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DOI：
10.7754/clin.lab.2018.180219
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发表时间：
2018-01-01
影响因子：
0.7
通讯作者：
Xue, Qun
中科院分区：
文献类型：
--
作者：
Bao, Minqiang;Hu, Renping;Xue, Qun
背景：帕金森病（PD）患者患心血管事件的风险较低，但这种风险降低的潜在因素尚不清楚。血清甘油三酯（TG）和总胆固醇（TC）及其相对于高密度脂蛋白胆固醇（TG/HDL-C和TC/HDL-C）的表达是心血管事件的独立预测因子。本研究旨在确定PD患者是否有降低的脂质水平和脂质比率，这可能是降低冠心病（CHD）风险的基础。方法：回顾性研究包括92例PD患者（PD组）、450例无冠心病对照（OD组）和450例冠心病患者（CHD组）。分析各组血清脂质水平及脂质比率。结果：三组患者TC （F = 10.459, p < 0.0001）、TG （F = 46.856, p < 0.0001）、低密度脂蛋白胆固醇（LDL-C） （F = 6.910, p = 0.001）、高密度脂蛋白胆固醇HDL-C （F = 30.694, p < 0.0001）、TC/HDL-C （F = 32.675, p < 0.0001）、TG/HDL-C （F = 45.554, p < 0.0001）差异均有统计学意义；TC/LDL-C组间差异无统计学意义（F = 2.518, p = 0.081）。与冠心病组相比，PD患者TC （p < 0.0001）、TG （p < 0.0001）、LDL-C （p = 0.001）、TG/HDL-C （p < 0.0001）和TC/HDL-C （p < 0.0001）均较低；TC/LDL-C （p = 0.563）、HDL-C （p = 0.196）差异无统计学意义。各组TC与LDL-C水平呈正相关（均p < 0.0001）。此外，OD组和CHD组TG与HDL-C呈负相关（p < 0.0001）；PD组无显著负相关（p = 0.077）。TG/HDL和LDL-C水平在冠心病组呈负相关（p < 0.0001），在PD组（p = 0.159）和OD组（p = 0.199）呈弱正相关（p = 0.199）。结论：PD患者TC/HDL和TG/HDL比值明显低于冠心病患者，提示脂质比值与PD患者冠心病发病率有较强相关性。
Background: Patients with Parkinson's disease (PD) are at a lower risk of suffering cardiovascular events, but the underlying factors for this decreased risk remain unclear. Serum triglycerides (TG) and total cholesterol (TC), and their expression relative to high-density lipoprotein cholesterol (TG/HDL-C and TC/HDL-C), are independent predictors of cardiovascular events. This study aimed to determine if PD patients have decreased lipid levels and lipid ratios, which may underlie the decreased risk of coronary heart disease (CHD).Methods: This retrospective study included 92 PD patients (PD group), 450 control subjects with no CHD (OD group), and 450 CHD patients (CHD group). We analyzed serum lipid levels and lipid ratios in each group.Results: There were significant differences in TC (F = 10.459, p < 0.0001), TG (F = 46.856, p < 0.0001), low density lipoprotein cholesterol (LDL-C) (F = 6.910, p = 0.001), high density lipoprotein cholesterol HDL-C (F = 30.694, p < 0.0001), TC/HDL-C (F = 32.675, p < 0.0001), and TG/HDL-C (F = 45.554, p < 0.0001) between all three groups; TC/LDL-C (F = 2.518, p = 0.081) was not significantly different between groups. Compared to the CHD group, PD patients had lower TC (p < 0.0001), TG (p < 0.0001), LDL-C (p = 0.001), TG/HDL-C (p < 0.0001), and TC/HDL-C (p < 0.0001); TC/LDL-C (p = 0.563) and HDL-C (p = 0.196) were not significantly different. TC and LDL-C levels were positively correlated within individual groups (all p < 0.0001). In addition, TG and HDL-C were negatively correlated in the OD and CHD groups (p < 0.0001); no significant negative association was observed in the PD group (p = 0.077). TG/HDL and LDL-C levels were inversely correlated in the CHD group (p < 0.0001) and weakly positively correlated in the PD (p = 0.159) and OD (p = 0.199) groups.Conclusions: TC/HDL and TG/HDL ratios were significantly lower in PD patients compared to CHD patients, suggesting there is a strong correlation between lipid ratios and incidence of CHD in PD patients.