Positive association between heart dosimetry parameters and a novel cardiac biomarker, solubleST-2, in thoracic cancer chest radiation
Positive association between heart dosimetry parameters and a novel cardiac biomarker, solubleST-2, in thoracic cancer chest radiation
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胸癌胸部放射中心脏剂量测定参数与新型心脏生物标志物可溶性 ST-2 之间的正相关
DOI：
10.1002/jcla.23150
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发表时间：
2020
影响因子：
2.7
通讯作者：
Liu An-wen
中科院分区：
文献类型：
--
作者：
Zeng Zhi-min;Xu Peng;Zhou Shan;Du Hai-yang;Jiang Xiao-liu;Cai Jing;Huang Long;Liu An-wen
背景：胸部辐射暴露患者的辐射诱发性心脏病（RIHD）的筛查和诊断是困难的。sST‐2参与心肌应激或损伤。我们评估了接受胸部放射治疗的胸部恶性肿瘤患者心脏剂量参数与sST‐2变化之间的关系。方法前瞻性收集接受胸部放疗的胸部恶性肿瘤患者。从治疗计划系统中提取心脏剂量学参数。在基线、中期和放疗后测量sST‐2（记录为ST‐2前、ST‐2中期和ST‐2后）。计算sST‐2变化率。散点图显示心脏剂量参数与ST‐2变化率之间的关系。采用多元回归分析心脏剂量参数与ST‐2变化率之间的关系。结果共纳入60例患者。意味着V5, V10 V20、V30 V40,和磁流体动力为60.93±27.79%,51.43±25.44%,39.17±21.75%,28.07±17.15%,18.66±12.18%,分别为18.60±8.63 Gy。中位M - LAD为11.31 Gy （IQR为3.33 - 18.76）。ST‐2前、ST‐2中期和ST‐2后的平均值分别为5.1±3.8、6.4±3.9和7.6±4.4。胸椎照射后sST‐2升高（P< 0.001）。多元线性回归分析显示，V5、V10、V20和MHD与ST‐2变化率呈独立正相关（β= 0.04, p < 0.05）。04。04，和。10例，p均< 0.05)。结论放疗期间血清sST‐2水平随时间升高。V5、V10、v20和MHD与升高的ST‐2变化率独立且正相关。
BackgroundEarly screening and diagnosis of radiation‐induced heart disease (RIHD) is difficult in patients with chest radiation exposure. sST‐2 is involved in myocardial stress or injury. We evaluated the relationship between heart dose parameters and sST‐2 changes in chest malignant tumor patients who received chest radiation.MethodsWe prospectively collected thoracic malignancy cancer patients who had received chest radiotherapy. Heart dosimetry parameters were extracted from the treatment planning system. sST‐2 was measured at baseline, the middle stage, and after radiotherapy (recorded as pre‐ST‐2, mid‐ST‐2, and post‐ST‐2). sST‐2 change rate was calculated. Scatter plots showed the relationship between cardiac dose parameters and ST‐2 change rate. Multiple regression was used to analyze the relationship between cardiac dose parameters and ST‐2 change rate.ResultsTotally, 60 patients were enrolled. The mean V5, V10, V20, V30, V40, and MHD was 60.93 ± 27.79%, 51.43 ± 25.44%, 39.17 ± 21.75%, 28.07 ± 17.15%,18.66 ± 12.18%, and 18.60 ± 8.63 Gy, respectively. The median M‐LAD was 11.31 (IQR 3.33‐18.76) Gy. The mean pre‐ST‐2, mid‐ST‐2, and post‐ST‐2 was 5.1 ± 3.8, 6.4 ± 3.9, and 7.6 ± 4.4, respectively. sST‐2 was elevated with thoracic irradiation (P< .001). Multivariate linear regression analyses showed that V5, V10, V20, and MHD were independently and positively associated with ST‐2 change rate (β= .04, .04, .04, and .10, respectively, allP< .05).ConclusionSerum sST‐2 levels were elevated over time during radiotherapy. V5, V10, V20and MHD were independently and positively associated with the elevated ST‐2 change rate.