Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson's disease
Neuroprotective actions of the ginseng extract G115 in two rodent models of Parkinson's disease
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DOI：
10.1016/j.expneurol.2003.08.002
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发表时间：
2003-11-01
影响因子：
5.3
通讯作者：
Drobitch, R
中科院分区：
文献类型：
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作者：
Van Kampen, J;Robertson, H;Drobitch, R
草药人参最近被证明具有神经营养和神经保护特性，这可能有助于预防各种形式的神经元细胞损失，包括帕金森病（PD）中看到的黑质纹状体变性。在这些研究中，我们研究了人参提取物g115在两种帕金森病啮齿动物模型中的潜在神经保护作用。在小鼠暴露于诱发帕金森病的神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）或大鼠暴露于其毒性代谢物1-甲基-4-苯基吡啶（MPP+）之前和/或之后，动物口服G115。这种治疗显著地阻断了黑质中酪氨酸羟化酶阳性细胞的丢失，减少了运动功能障碍的出现。因此，口服人参似乎对PD啮齿动物模型的神经毒性提供保护。进一步研究人参及其各种成分的神经保护作用可能为减缓帕金森病的进展提供一种潜在的手段。(C) 2003 Elsevier Inc.版权所有。
The herbal remedy, ginseng, has recently been demonstrated to possess neurotrophic and neuroprotective properties, which may be useful in preventing various forms of neuronal cell loss including the nigrostriatal degeneration seen in Parkinson's disease (PD). In these studies, we examine the potential neuroprotective actions of the ginseng extract, G 115, in two rodent models of PD. Animals received oral administration of G115 prior to and/or following exposure to the parkinsonism-inducing neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), in mice, or its toxic metabolite, 1-methyl-4-phenylpyridinium (MPP+), in rats. Such treatment significantly and dramatically blocked tyrosine hydroxylase-positive cell loss in the substantia nigra and reduced the appearance of locomotor dysfunction. Thus, oral administration of ginseng appears to provide protection against neurotoxicity in rodent models of PD. Further examination of the neuroprotective actions of ginseng and its various elements may provide a potential means of slowing the progress of PD. (C) 2003 Elsevier Inc. All rights reserved.