Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy
Intramyocellular lipid accumulation and reduced whole body lipid oxidation in HIV lipodystrophy
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DOI：
10.1152/ajpendo.00391.2001
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发表时间：
2003-02-01
影响因子：
5.1
通讯作者：
Lazzarin, A
中科院分区：
文献类型：
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作者：
Luzi, L;Perseghin, G;Lazzarin, A
人类免疫缺陷病毒（HIV）阳性患者的抗逆转录病毒治疗可诱导外周脂肪消耗和中枢性肥胖、血脂异常和胰岛素抵抗的脂肪代谢障碍综合征。为了检测胰岛素抵抗是否与脂肪酸的异常肌肉处理有关，研究了12名HIV-1患者（8名女性/4名男性，年龄=26 ± 2岁，HIV持续时间=8 ± 1年，体重指数=22.0 ± 1.0 kg/m2，服用蛋白酶抑制剂和核苷类似物RT抑制剂）和12名健康受试者。HIV-1患者的全身脂肪含量（通过双能X线吸收测定法评估）与对照组相似（22+/-1 vs. 23+/-2%; P=0.56），局部脂肪再分布的特征是腿部脂肪含量减少（18+/-2 vs. 32+/-3%; P
Antiretroviral therapy in human immunodeficiency virus (HIV)-positive patients can induce a lipodystrophy syndrome of peripheral fat wasting and central adiposity, dyslipidemia, and insulin resistance. To test whether in this syndrome insulin resistance is associated with abnormal muscle handling of fatty acids, 12 HIV-1 patients (8 females/4 males, age=26+/-2 yr, HIV duration=8+/-1 yr, body mass index=22.0+/-1.0 kg/m(2), on protease inhibitors and nucleoside analog RT inhibitors) and 12 healthy subjects were studied. HIV-1 patients had a total body fat content (assessed by dual-energy X-ray absorptiometry) similar to that of controls (22+/-1 vs. 23+/-2%; P=0.56), with a topographic fat redistribution characterized by reduced fat content in the legs (18+/-2 vs. 32+/-3%; P