Rabbit classical eyeblink conditioning is altered by brief cerebellar cortical stimulation.
Rabbit classical eyeblink conditioning is altered by brief cerebellar cortical stimulation.
复制标题
短暂的小脑皮质刺激会改变兔子的经典眨眼条件反射。
DOI：
10.1016/s0031-9384(00)00444-3
复制
发表时间：
2001
影响因子：
2.9
通讯作者：
Steinmetz,JE
中科院分区：
文献类型：
--
作者：
Katz,DB;Tracy,JA;Steinmetz,JE
一对研究检查了皮质小脑内刺激（ICS）如何影响兔子的眨眼条件反射。在家兔小脑H-VI小叶细胞体层植入慢性双极刺激电极。在训练试验中，给予短时间（40 ms）的颅内刺激（100 Hz, 250 μA）[音调条件刺激（CS）与吹气非条件刺激（US）的正向配对]。在实验1中，ICS的发作在会话中随机变化。与在美国发病前60毫秒结束的ICS相比，美国发病同步的ICS证明对条件反射的维持是有害的[以产生条件反应（cr）的试验百分比来衡量]。基于这些发现，第二项实验比较了在美国开始时持续提供ICS训练的组，在CS开始时或在两个刺激之间持续提供ICS训练的组，以及未受刺激的对照组。接受CS或us同步ICS的动物学习速度最慢，而接受中等刺激的动物学习速度比其他所有组都快。在实验1和2中，训练有素的动物对刺激的直接反应是眨眼。这些数据被讨论在一个新的假设关于小脑皮层和小脑深部核之间的相互作用，在眨眼条件反射-从抑制假说反弹。
A pair of studies examined how cortical intracerebellar stimulation (ICS) affects eyeblink conditioning in the rabbit. Rabbits were implanted with chronic bipolar stimulating electrodes in the cell body layers of cerebellar lobule H-VI. Brief (40 ms) trains of intracranial stimulation (100 Hz, 250 μA) were delivered during training trials [forward pairings of a tone-conditioned stimulus (CS) with an air puff unconditioned stimulus (US)]. In Experiment 1, the onset of ICS varied randomly within sessions. US-onset-coincident ICS proved detrimental to the maintenance of conditioning [measured as the percentage of trials on which conditioned responses (CRs) were made] compared to ICS that ended 60 ms before US onset. Based on these findings, a second experiment compared a group trained with ICS consistently delivered at US onset to groups trained with ICS consistently delivered either at CS onset or between the two stimuli, as well as to unstimulated control subjects. Animals receiving CS- or US-coincident ICS learned slowest, whereas animals receiving middle stimulation learned more quickly than all other groups. In both Experiments 1 and 2, highly trained animals produced blinks in direct response to the stimulation. These data are discussed in terms of a new hypothesis concerning interactions between cerebellar cortex and the deep cerebellar nuclei during eyeblink conditioning — a rebound from inhibition hypothesis.