SYNTHETIC LOW-MOLECULAR WEIGHT INHIBITORS OF SERUM KALLIKREIN
SYNTHETIC LOW-MOLECULAR WEIGHT INHIBITORS OF SERUM KALLIKREIN
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DOI：
10.1016/0006-2952(74)90554-1
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发表时间：
1974-01-01
影响因子：
5.8
通讯作者：
WALSMANN, P
中科院分区：
文献类型：
--
作者：
MARKWARDT, F;DRAWERT, J;WALSMANN, P
研究了苄胺、苯甲脒和苯胍衍生物对血清激肽释放酶活性的影响，并推导了构效关系。在所测试的物质中，发现了血清激肽释放酶的竞争性、暂时性和不可逆性抑制剂，本文描述了这三类抑制剂，并讨论了它们作为体内激肽释放的有效抑制剂的可能用途。
The influence of derivatives of benzylamine, benzamidine and phenylguanidine on the activity of serum kallikrein was investigated, and structure-activity relationships were derived. Among the substances tested, competitive, temporary and irreversible inhibitors of serum kallikrein were found. These three types of inhibitors are described and their possible use as effective inhibitors of kinin liberationin vivois discussed.