Assessment of the exhalation kinetics of volatile cancer biomarkers based on their physicochemical properties.
Assessment of the exhalation kinetics of volatile cancer biomarkers based on their physicochemical properties.
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DOI：
10.1088/1752-7155/8/1/016003
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发表时间：
2014-03
影响因子：
3.8
通讯作者：
Haick H
中科院分区：
文献类型：
--
作者：
Amann A;Mochalski P;Ruzsanyi V;Broza YY;Haick H
目前的审查提供了与癌症有关的挥发性有机化合物（VOCs）的呼气动力学评估。为此，我们评估各种物理化学性质，如“呼吸：空气”和“血液：脂肪”分配系数，112挥发性有机化合物，已建议在过去十年中作为潜在的癌症标志物。通过这些数据，我们表明血液和脂肪中的癌症VOC浓度分别跨越12和8个数量级，以便在呼出气中提供特定的对应物浓度（例如，1 ppb）。这一发现表明，这112种不同的化合物在体内具有不同的储存室，并且它们的呼气动力学取决于以下因素中的一个或组合：（i）身体不同部位的VOC浓度;（ii）VOC合成和代谢速率;（iii）组织、血液和空气之间的分配系数;以及（iv）VOC的扩散常数。基于这种分析，我们讨论了这种知识如何允许在不同的采样协议（有和没有努力）下建模和模拟特定VOC的行为。最后，我们简要讨论了这些方案在癌症筛查和治疗监测中的潜在作用。
The current review provides an assessment of the exhalation kinetics of volatile organic compounds (VOCs) that have been linked with cancer. Towards this end, we evaluate various physicochemical properties, such as ‘breath:air’ and ‘blood:fat’ partition coefficients, of 112 VOCs that have been suggested over the past decade as potential markers of cancer. With these data, we show that the cancer VOC concentrations in the blood and in the fat span over 12 and 8 orders of magnitude, respectively, in order to provide a specific counterpart concentration in the exhaled breath (e.g., 1 ppb). This finding suggests that these 112 different compounds have different storage compartments in the body and that their exhalation kinetics depends on one or a combination of the following factors: (i) the VOC concentrations in different parts of the body; (ii) the VOC synthesis and metabolism rates; (iii) the partition coefficients between tissue(s), blood and air; and (iv) the VOCs’ diffusion constants. Based on this analysis, we discuss how this knowledge allows modeling and simulating the behavior of a specific VOC under different sampling protocols (with and without exertion of effort). We end this review by a brief discussion on the potential role of these scenarios in screening and therapeutic monitoring of cancer.