Characterization of thyroid function and antithyroid antibody tests among Saudis.
Characterization of thyroid function and antithyroid antibody tests among Saudis.
复制标题
DOI：
10.15537/smj.2015.6.11591
复制
发表时间：
2015-06
影响因子：
1.6
通讯作者：
Alzahrani SH
中科院分区：
文献类型：
--
作者：
Jammah AA;Alshehri AS;Alrakhis AA;Alhedaithy AS;Almadhi AM;Alkwai HM;Alhamad MM;Alzahrani SH
确定沙特人群甲状腺功能检查的参考间隔和甲状腺自身免疫的患病率。2013年1月至6月在沙特阿拉伯利雅得哈立德国王大学医院进行了一项横断面前瞻性研究。获得病史和体格检查。采用电化学发光免疫系统法测定促甲状腺激素（TSH）、游离甲状腺素（FT4）和游离三碘甲状腺原氨酸（FT3）。采用酶联免疫吸附法测定抗甲状腺过氧化物酶和抗甲状腺球蛋白抗体。排除既往有甲状腺疾病史或家族史、服用影响甲状腺功能药物者、孕妇或哺乳期妇女以及甲状腺肿大者。抗体阳性的个体被排除在TSH参考范围的最终分析之外，但用于确定甲状腺自身免疫的患病率。在最初筛选的337名沙特受试者中，132名（13-60岁）作为参考计算的候选人，TSH （mIU/L）的平均值±标准差和（2.5 -97.5）个百分点为1.96±0.9 (0.59-4.37),FT4 （pmol/L）为15.47±1.83 (12.04-19.13),FT3 （pmol/L）为5.22±0.7（4.07-6.76）。抗体阳性组TSH（2.5±1.17 mIU/L）高于阴性组（1.96±0.9 mIU/L） （p<0.05）。最后，26%的受试者抗甲状腺抗体检测呈阳性。TSH参考范围与实验室参考相似。甲状腺抗体在沙特人中普遍存在，需要进一步开展更大规模的研究。
To determine the reference intervals for thyroid function tests and the prevalence of thyroid autoimmunity in the Saudi population. A cross-sectional prospective study was conducted in King Khalid University Hospital, Riyadh, Saudi Arabia from January to June 2013. History and physical examination were obtained. Thyroid-stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were measured by Electro-chemiluminescence Immunoassay system-assay. Anti-thyroperoxidase, and anti-thyroglobulin antibodies were measured using enzyme-linked immunosorbent-assay. Subjects with previous or a family history of thyroid disorders, those taking medications affecting thyroid function, pregnant or lactating women, and those with goiter were excluded. Individuals with positive antibodies were excluded from the final analysis of the TSH reference range, but were used to determine the prevalence of thyroid autoimmunity. Out of 337 Saudi subjects initially screened, 132 (aged 13-60 years) were candidates for reference calculation, the mean±standard deviation, and (2.5th-97.5th) percentile of TSH (mIU/L) was 1.96±0.9 (0.59-4.37), for FT4 (pmol/L) was 15.47±1.83 (12.04-19.13), and for FT3 (pmol/L) was 5.22±0.7 (4.07-6.76). The TSH was higher in the antibodies positive group (2.5±1.17 mIU/L) compared with the negative one (1.96±0.9 mIU/L) (p<0.05). Finally, 26% of subjects were tested positive for antithyroid antibodies. The TSH reference range was similar to laboratory references. Thyroid antibodies were prevalent in Saudis, necessitating further work in larger scale studies.