Transcriptional control of osteoblast differentiation
Transcriptional control of osteoblast differentiation
复制标题
DOI：
10.1042/bst0260014
复制
发表时间：
1998-02-01
影响因子：
3.9
通讯作者：
van Wijnen, AJ
中科院分区：
文献类型：
--
作者：
Lian, JB;Stein, GS;van Wijnen, AJ
祖干细胞向成骨细胞谱系细胞的定型和逐步分化是由一系列复杂的信号通路介导的事件。我们的研究重点是鉴定驱动成骨细胞成熟所需基因表达的转录因子。同样重要的是了解当干细胞变成骨祖细胞时缓解干细胞中骨特异性基因抑制的因素。在这种情况下，参与骨特异性骨钙素基因表达的转录因子复合物的表征揭示了理解成骨细胞分化的新因素和新见解。在这里，我们描述了介导骨钙素基因转录的分子机制，该基因与成骨细胞分化的控制相结合。其中包括核结构的贡献以及 Fos/Jun 家族成员、同源域蛋白和核心结合因子 (CBFx)/急性髓性白血病 (AML) 因子在调节骨形成中的影响。
Commitment and progressive differentiation of a progenitor stem cell to osteoblast lineage cells are events mediated by a complex series of signalling pathways. Our studies have focused on identification of the transcription factors which drive the expression of genes required for maturation of osteoblasts. Equally important is an understanding of the factors that relieve suppression of bone-specific genes in stem cells when they become osteoprogenitor cells. In this context, characterization of the transcription factor complexes involved in expression of the bonespecific osteocalcin gene has revealed novel factors and new insights for understanding osteoblast differentiation. Here we describe the molecular mechanisms mediating transcription of the osteocalcin gene that are coupled to the control of osteoblast differentiation. These include the contributions of nuclear structure and the influence of Fos/Jun family members, homeodomain proteins, and the core binding factor (CBFx)/acute myelogenous leukaemia (AML) factors in regulating bone formation.