NIR-Activated "OFF/ON" Photodynamic Therapy by a Hybrid Nanoplatform with Upper Critical Solution Temperature Block Copolymers and Gold Nanorods
NIR-Activated "OFF/ON" Photodynamic Therapy by a Hybrid Nanoplatform with Upper Critical Solution Temperature Block Copolymers and Gold Nanorods
复制标题
通过具有上临界溶液温度嵌段共聚物和金纳米棒的混合纳米平台进行近红外激活的“关/开”光动力疗法
DOI：
10.1021/acs.biomac.9b00963
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发表时间：
2019-10-01
影响因子：
6.2
通讯作者：
Zhang, Weian
中科院分区：
文献类型：
--
作者：
Huang, Baoxuan;Tian, Jia;Zhang, Weian
光动力疗法（PDT）因其微创性和可忽略的耐药性而成为一种有前途的癌症治疗方式。然而，传统光敏剂的缺点，包括普遍聚集引起的猝灭（ACQ）效应或非选择性激活，仍然是PDT临床应用的主要障碍。在此，通过将卟啉单元引入到上临界溶液温度（UCST）嵌段共聚物装饰的金纳米棒（AuNR-P（AAm-co-AN-co-TPP）-b-PEG）中，提出了一种灵活操纵光敏剂以有效猝灭和快速恢复光活化的新策略。 UCST嵌段共聚物在生理温度下可通过π-π堆积和氢键相互作用实现自猝灭效应，使卟啉光敏剂处于“关闭”状态，大大降低了光敏剂的非选择性光毒性，满足避光光疗的要求。AuNR-P(AAm-co-AN-co-TPP)-b-PEG纳米粒子迁移到肿瘤组织并被癌细胞内化后，在近红外光照射下，UCST聚合物链可以在AuNRs的局部加热下延伸，然后卟啉光敏剂被“打开”，从而显着提高PDT效率。因此，UCST嵌段共聚物和AuNRs的混合纳米平台可以很好地控制PDT过程的“关闭/打开”状态，这将为PDT的临床治疗开辟新的视野。
Photodynamic therapy (PDT) is a promising treatment modality for cancer treatment owing to its minimally invasive nature and negligible drug resistance. However, the disadvantages of conventional photosensitizers including universal aggregation-caused quenching (ACQ) effect or nonselective activation are still major hurdles for PDT clinical application. Herein, a new strategy for flexible manipulating photosensitizers in effective quenching and quick recovery of photoactivation is presented by introducing porphyrin units into upper critical solution temperature (UCST) block copolymer decorated gold nanorods (AuNR-P(AAm-co-AN-co-TPP)-b-PEG). The UCST block copolymer can achieve a self-quenching effect to make the porphyrin photosensitizers in the "Off' state by pi-pi stacking and hydrogen bonding interactions at physiological temperature, which greatly minimizes the nonselective phototoxicity of the photosensitizers to meet the requirement of phototherapy protected from sunlight. After the immigration of AuNR-P(AAm-co-AN-co-TPP)-b-PEG nanoparticles into the tumor tissue and the internalization by cancer cells, the UCST polymer chains can be extended under the local heating of AuNRs by NIR light irradiation, and then porphyrin photosensitizers are turned "On" to dramatically boost the PDT efficiency. Therefore, the process of PDT could be well manipulated in the "Off/On" state by the hybrid nanoplatform with UCST block copolymers and AuNRs, which will open new horizons for clinical treatments of PDT.