Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop
Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop
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DOI：
10.1016/j.ajog.2004.03.004
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发表时间：
2004-10-01
影响因子：
9.8
通讯作者：
McClure, N
中科院分区：
文献类型：
--
作者：
McKeeman, GC;Ardill, JES;McClure, N
目的：本研究旨在分析整个血压正常和先兆子痫妊娠期间的前瞻性循环血管内皮生长因子 (VEGF) 及其可溶性受体 (s) Flt-1，并评估这些蛋白质在先兆子痫发生中的重要性。 研究设计：在这项纵向队列研究中，从妊娠期间 12、20、30、 以及37周以及产前和产后24小时内。受试者被回顾性地分为血压正常组和先兆子痫组。分别采用放射免疫法和酶联免疫吸附法分析循环VEGF和sFlt-1浓度。结果：随着妊娠的进展，循环sFlt-1和VEGF显着升高，与正常血压妊娠相比，子痫前期两者的浓度进一步升高。可溶性 Flt-1 浓度在妊娠早期升高，并且在随后发生先兆子痫的妊娠 30 周时显着升高。结论：这些结果表明 sFlt-1 浓度升高与先兆子痫发作之间存在明确关联，表明 sFlt-1 与疾病发病机制有关。 (C) 2004 Elsevier Inc. 保留所有权利。
Objective: This study was undertaken to analyze prospectively circulating vascular endothelial growth factor (VEGF) and its soluble receptor, (s) Flt-1, throughout normotensive and preeclamptic pregnancies and to assess the importance of these proteins in the development of preeclampsia.Study design: In this longitudinal cohort study, serum samples were collected from recruited subjects throughout pregnancy at 12, 20, 30, and 37 weeks and in the 24 hours before and after delivery. Subjects were divided retrospectively into normotensive and preeclamptic groups. Circulating VEGF and sFlt-1 concentrations were analyzed by radioimmunoassay and enzyme-linked immunosorbent assay, respectively.Results: Circulating sFlt-1 and VEGF significantly increased as gestation progressed and both were further elevated in preeclampsia compared with normotensive pregnancy. Soluble Flt-1 concentrations were elevated early in gestation and were significantly increased at 30 weeks' gestation in those who subsequently developed preeclampsia.Conclusion: These results indicate a definite association between elevated sFlt-1 concentrations and the onset of preeclampsia suggesting that sFlt-1 is linked with disease pathogenesis. (C) 2004 Elsevier Inc. All rights reserved.