Evaluating Variability in Tumor Measurements from Same-day Repeat CT Scans of Patients with Non-Small Cell Lung Cancer
Evaluating Variability in Tumor Measurements from Same-day Repeat CT Scans of Patients with Non-Small Cell Lung Cancer
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DOI：
10.1148/radiol.2522081593
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发表时间：
2009-07-01
期刊：
影响因子：
19.7
通讯作者：
Schwartz, Lawrence H.
中科院分区：
文献类型：
--
作者：
Zhao, Binsheng;James, Leonard P.;Schwartz, Lawrence H.
目的：为了评估肿瘤一维，二维和体积测量的变异性，同一天重复计算机断层扫描（CT）扫描在非小细胞肺癌patients with non-small cell lung cancer.Materials and Methods：这符合HIPAA的研究是由机构审查委员会批准的，患者知情同意。32例非小细胞肺癌患者均在15分钟内使用相同的成像方案进行了两次胸部CT扫描。三名放射科医生在两次扫描中独立测量每个病灶的两个最大直径，并在另一次扫描中测量第一次扫描中的相同肿瘤。在一项单独的分析中，应用计算机软件辅助计算两次扫描中每个病灶的两个最大直径和体积。结果：三位放射科医师测量的重复性和重复性均较高（均大于0.96）。计算机辅助测量的再现性甚至更高（所有CCC，1.00）。两次重复扫描的计算机辅助一维、二维和体积测量的95%符合率分别为（-7.3%，6.2%）、（-17.6%，19.8%）和（-12.1%，13.4%）。8%或更大的一维病变尺寸的变化超过计算机方法的测量变异性，并且在估计患者的治疗结果时可以被认为是显著的。(C)RSNA，2009年
Purpose: To evaluate the variability of tumor unidimensional, bidimensional, and volumetric measurements on same-day repeat computed tomographic (CT) scans in patients with non-small cell lung cancer.Materials and Methods: This HIPAA-compliant study was approved by the institutional review board, with informed patient consent. Thirty-two patients with non-small cell lung cancer, each of whom underwent two CT scans of the chest within 15 minutes by using the same imaging protocol, were included in this study. Three radiologists independently measured the two greatest diameters of each lesion on both scans and, during another session, measured the same tumors on the first scan. In a separate analysis, computer software was applied to assist in the calculation of the two greatest diameters and the volume of each lesion on both scans. Concordance correlation coefficients (CCCs) and Bland-Altman plots were used to assess the agreements between the measurements of the two repeat scans (reproducibility) and between the two repeat readings of the same scan (repeatability).Results: The reproducibility and repeatability of the three radiologists' measurements were high (all CCCs, >= 0.96). The reproducibility of the computer-aided measurements was even higher (all CCCs, 1.00). The 95% limits of agreements for the computer-aided unidimensional, bidimensional, and volumetric measurements on two repeat scans were (-7.3%, 6.2%), (-17.6%, 19.8%), and (-12.1%, 13.4%), respectively.Conclusion: Chest CT scans are well reproducible. Changes in unidimensional lesion size of 8% or greater exceed the measurement variability of the computer method and can be considered significant when estimating the outcome of therapy in a patient. (C) RSNA, 2009