Statistics of soft-tissue sarcoma in Japan: Report from the Bone and Soft Tissue Tumor Registry in Japan
Statistics of soft-tissue sarcoma in Japan: Report from the Bone and Soft Tissue Tumor Registry in Japan
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DOI：
10.1016/j.jos.2017.03.017
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发表时间：
2017-07-01
影响因子：
1.7
通讯作者：
Kawai, Akira
中科院分区：
文献类型：
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作者：
Ogura, Koichi;Higashi, Takahiro;Kawai, Akira
背景：到目前为止，还没有以前的报告描述软组织肉瘤（STS）的国家概况。在本研究中，我们使用日本全国性骨和软组织肿瘤器官特异性癌症登记处（骨和软组织肿瘤（BSTT）登记处）的数据，回顾了日本STS的当前实践。在登记研究中，我们确定了2006-2012年期间8228例STS患者，并提取了患者人口统计学、治疗、以及每例患者末次随访时的结局。疾病特异性生存率采用考克斯比例风险模型进行分析。年龄分布在70岁时出现单峰，年龄>60岁的老年患者比例约为53%。对于大多数的组织学亚型，最常见的肿瘤位置是下肢，而在恶性外周神经鞘瘤，去分化脂肪肉瘤和原始神经外胚层肿瘤的患者中，它是躯干。基于2432例STS患者的数据，我们发现疾病特异性生存率与年龄、性别、组织学亚型、肿瘤大小、肿瘤深度、肿瘤位置、额外手术、保肢状态和手术切缘之间存在显著相关性;老年患者的疾病特异性生存率最低。使用BSTT登记，本研究阐明了日本STS患者的流行病学，治疗和预后。我们在BSTT登记处的经验将有助于其他正在发生人口老龄化的国家。BSTT登记研究中不断积累的临床数据应提供更多关于STS的信息数据，从而通过共享这些数据和促进临床研究来提高临床医生提供的医疗护理水平和患者的结局。(C)2017作者由Elsevier B. V.代表日本骨科协会出版。
Background: No previous reports to date have characterized the national profiles of soft-tissue sarcomas (STSs). In the present study, we reviewed current practice for STSs in Japan using data from a nationwide organ-specific cancer registry for bone and soft-tissue tumors in Japan, the Bone and Soft Tissue Tumor (BSTT) Registry.Methods: In the registry, we identified 8228 patients with STSs during the period 2006-2012, and extracted data on patient demographics, treatment, and outcome at the last follow-up for each patient. Disease-specific survival was analyzed using the Cox proportional hazards model.Results: STSs showed a slight male predilection. The age distribution had a single peak in the seventh decade, the proportion of elderly patients aged >60 years being approximately 53%. For most of the histologic subtypes, the most frequent tumor location was the lower extremity, whereas it was the trunk in patients with malignant peripheral nerve sheath tumor, dedifferentiated liposarcoma, and primitive neuroectodermal tumor. Based on data for 2432 patients with STSs, we found significant associations between disease-specific survival and age, sex, histologic subtype, tumor size, tumor depth, tumor location, additional surgery, limb salvage status, and surgical margin; elderly patients showed the poorest disease-specific survival.Conclusions: Using the BSTT Registry, this study has clarified the epidemiology, treatment, and prognosis of patients with STSs in Japan. Our experiences with the BSTT Registry will be of help to other countries where aging of the population is occurring. Continuous accumulation of clinical data in the BSTT Registry should provide more informative data on STSs, thus improving both the level of medical care offered by clinicians and the outcomes for patients through sharing of such data and promotion of clinical research. (C) 2017 The Authors. Published by Elsevier B.V. on behalf of The Japanese Orthopaedic Association.