A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging.
A Multimodality Hybrid Gamma-Optical Camera for Intraoperative Imaging.
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DOI：
10.3390/s17030554
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发表时间：
2017-03-09
期刊：
影响因子：
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通讯作者：
Perkins AC
中科院分区：
文献类型：
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作者：
Lees JE;Bugby SL;Alqahtani MS;Jambi LK;Dawood NS;McKnight WR;Ng AH;Perkins AC
低剖面伽马射线探测器的发展促进了用于患者床边和手术室的小视场（SFOV）手持式成像设备的生产。这些SFOV相机的早期开发集中在单一模态伽马射线成像上。最近，一种混合系统伽马加光学成像已经开发出来。光学和伽马相机的这种组合能够实现高空间分辨率的多模态成像，给出叠加的衍射和光学图像。混合成像提供了新的可能性，以协助临床医生和外科医生在定位的网站摄取的程序，如前哨淋巴结检测。混合相机的概念可以扩展到多模式检测器设计，可以提供立体图像，伽马发射源的深度估计，以及同时伽马和荧光成像。最近改进的混合相机已被用来产生双模态图像在实验室模拟和临床。混合成像的病人谁接受甲状腺造影报告。此外，我们目前的数据表明，混合相机的概念可以扩展到估计的位置和深度的放射性核素分布在一个对象，也报告了第一个结合伽马和近红外（NIR）荧光图像。
The development of low profile gamma-ray detectors has encouraged the production of small field of view (SFOV) hand-held imaging devices for use at the patient bedside and in operating theatres. Early development of these SFOV cameras was focussed on a single modality—gamma ray imaging. Recently, a hybrid system—gamma plus optical imaging—has been developed. This combination of optical and gamma cameras enables high spatial resolution multi-modal imaging, giving a superimposed scintigraphic and optical image. Hybrid imaging offers new possibilities for assisting clinicians and surgeons in localising the site of uptake in procedures such as sentinel node detection. The hybrid camera concept can be extended to a multimodal detector design which can offer stereoscopic images, depth estimation of gamma-emitting sources, and simultaneous gamma and fluorescence imaging. Recent improvements to the hybrid camera have been used to produce dual-modality images in both laboratory simulations and in the clinic. Hybrid imaging of a patient who underwent thyroid scintigraphy is reported. In addition, we present data which shows that the hybrid camera concept can be extended to estimate the position and depth of radionuclide distribution within an object and also report the first combined gamma and Near-Infrared (NIR) fluorescence images.