Presymptomatic hippocampal atrophy in Alzheimer's disease - A longitudinal MRI study
Presymptomatic hippocampal atrophy in Alzheimer's disease - A longitudinal MRI study
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DOI：
10.1093/brain/119.6.2001
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发表时间：
1996-12-01
期刊：
影响因子：
14.5
通讯作者：
Rossor, MN
中科院分区：
文献类型：
--
作者：
Fox, NC;Warrington, EK;Rossor, MN
从病理学和磁共振成像（MRI）研究可知，在确诊的阿尔茨海默病中，海马结构（HF）严重萎缩。然而，尚不清楚海马结构最早何时发生变化。我们对有常染色体显性家族性阿尔茨海默病风险的无症状个体进行了一项纵向研究，以评估海马结构的症状前变化。一个与淀粉样前体蛋白717缬氨酸到甘氨酸突变相关的家族性阿尔茨海默病家系中的7名高危成员在3年多的时间里接受了系列磁共振扫描和神经心理学评估。将这些评估结果与38名正常对照者的结果进行了比较。在研究期间，3名高危受试者出现了临床症状。对海马结构的体积测量显示，在这些受试者出现症状之前就出现了不对称萎缩。言语和视觉记忆能力的下降与海马体的萎缩同时发生。在首次出现症状的2年里，海马结构的体积每年减少多达8%。这些发现可能对阿尔茨海默病的早期诊断有启示意义。
The hippocampal formation (HF) is known from pathological and MRI studies to be severely atrophied in established Alzheimer's disease. However it is unclear when the earliest changes in the HF occur: We performed a longitudinal study of asymptomatic individuals at risk of autosomal dominant familial Alzheimer's disease in order to assess presymptomatic changes in the HF. Seven at risk members of a familial Alzheimer's disease pedigree associated with the amyloid precursor protein 717 valine to glycine mutation underwent serial MR scanning and neuropsychological assessments over 3 years. These assessments were compared with results from 38 normal controls. During the study three at risk subjects became clinically affected Volumetric measurement of the HF showed that asymmetrical atrophy developed in these subjects before the appearance of symptoms. Verbal and visual memory measures declined in parallel with hippocampal loss. A loss of up to 8% per annum of the volume of the HF occurred in the 2 years over which symptoms first appeared. These findings may have implications for early diagnosis of Alzheimer's disease.