Plasma adiponectin concentrations and correlates in African Americans in the Hypertension Genetic Epidemiology Network (HyperGEN) study.
Plasma adiponectin concentrations and correlates in African Americans in the Hypertension Genetic Epidemiology Network (HyperGEN) study.
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高血压遗传流行病学网络 (HyperGEN) 研究中非裔美国人的血浆脂联素浓度及其相关性。
DOI：
10.1016/j.metabol.2007.03.020
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Oberman,Albert
中科院分区：
文献类型：
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作者：
Shikany,JamesM;Lewis,CoraE;Freedman,BarryI;Arnett,DonnaK;Leiendecker-Foster,Catherine;Jones,TamekiaL;Redden,DavidT;Oberman,Albert
脂联素具有胰岛素增敏、抗动脉粥样硬化和抗炎作用，可能是冠心病和糖尿病的重要危险因素。相对较少的血浆脂联素的研究包括相当数量的非洲裔美国人。本研究的目的是调查血浆脂联素浓度和这些浓度的相关性在非洲裔美国人。这是一项在高血压遗传流行病学网络中进行的横断面分析。这项研究包括211名血压正常的高血压兄弟姐妹的后代（年龄22-37岁），由高血压遗传流行病学网络伯明翰，AL，现场中心招募。除了测量血浆脂联素外，还收集了人口统计学和生活方式数据，并获得了人体测量，临床和实验室测量结果。平均血浆脂联素浓度为5.5 ± 3.8 μg/mL。女性的脂联素比男性高55%：分别为6.5 ± 4.4和4.2 ± 2.5 μg/mL（P <0.0001）。在多变量分析中，高密度脂蛋白胆固醇浓度与血浆脂联素浓度呈正相关，男性性别和胰岛素浓度与血浆脂联素浓度呈负相关。这些非裔美国人的血浆脂联素浓度低于其他种族/族裔群体，包括日本人、白人和皮马印第安人。血浆脂联素与其他因素的关联方向与其他种族/族裔群体的结果一致。
Adiponectin has demonstrated insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, and may be an important risk factor for coronary heart disease and diabetes. Relatively few previous studies of plasma adiponectin have included sizable numbers of African Americans. The objective of the study was to investigate plasma concentrations of adiponectin and correlates of these concentrations in African Americans. This was a cross-sectional analysis that took place within the Hypertension Genetic Epidemiology Network. This study included 211 normotensive offspring (aged 22-37 years) of hypertensive siblings recruited by the Hypertension Genetic Epidemiology Network Birmingham, AL, field center. In addition to measuring plasma adiponectin, demographic and lifestyle data were collected, and anthropometric, clinical, and laboratory measurements were obtained. Mean plasma adiponectin concentration was 5.5 ± 3.8 μg/mL. Adiponectin was 55% higher in women than in men: 6.5 ± 4.4 vs 4.2 ± 2.5 μg/mL, respectively (P < .0001). In a multivariable analysis, high-density lipoprotein cholesterol concentration was positively associated and male sex and insulin concentration were negatively associated with plasma adiponectin concentration. Plasma adiponectin concentrations in these African Americans were lower than those reported in other racial/ethnic groups, including Japanese, whites, and Pima Indians. The directions of the associations of plasma adiponectin with other factors were in agreement with results in other racial/ethnic groups.