Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition.
Identifying a novel role for the master regulator Tal1 in the Endothelial to Hematopoietic Transition.
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DOI：
10.1038/s41598-022-20906-0
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发表时间：
2022-10-10
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
Progress in the generation of Hematopoietic Stem and Progenitor Cells (HSPCs) in vitro and ex vivo has been built on the knowledge of developmental hematopoiesis, underscoring the importance of understanding this process. HSPCs emerge within the embryonic vasculature through an Endothelial-to-Hematopoietic Transition (EHT). The transcriptional regulator Tal1 exerts essential functions in the earliest stages of blood development, but is considered dispensable for the EHT. Nevertheless, Tal1 is expressed with its binding partner Lmo2 and it homologous Lyl1 in endothelial and transitioning cells at the time of EHT. Here, we investigated the function of these genes using a mouse embryonic-stem cell (mESC)-based differentiation system to model hematopoietic development. We showed for the first time that the expression of TAL1 in endothelial cells is crucial to ensure the efficiency of the EHT process and a sustained hematopoietic output. Our findings uncover an important function of Tal1 during the EHT, thus filling the current gap in the knowledge of the role of this master gene throughout the whole process of hematopoietic development.
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影响因子：
7.7
作者：
Bergiers I;Andrews T;Vargel Bölükbaşı Ö;Buness A;Janosz E;Lopez-Anguita N;Ganter K;Kosim K;Celen C;Itır Perçin G;Collier P;Baying B;Benes V;Hemberg M;Lancrin C
通讯作者：
Lancrin C
影响因子：
4.8
作者：
Andreucci, JJ;Grant, D;McDermott, JC
通讯作者：
McDermott, JC
影响因子：
2.6
作者：
Ismailoglu, Ismail;Yeamans, Gabriel;Kyba, Michael
通讯作者：
Kyba, Michael
影响因子：
64.8
作者：
Lis R;Karrasch CC;Poulos MG;Kunar B;Redmond D;Duran JGB;Badwe CR;Schachterle W;Ginsberg M;Xiang J;Tabrizi AR;Shido K;Rosenwaks Z;Elemento O;Speck NA;Butler JM;Scandura JM;Rafii S
通讯作者：
Rafii S
影响因子：
16
作者：
Heinz S;Benner C;Spann N;Bertolino E;Lin YC;Laslo P;Cheng JX;Murre C;Singh H;Glass CK
通讯作者：
Glass CK