Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma
Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma
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DOI：
10.1007/s10014-012-0127-8
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发表时间：
2014-01-01
影响因子：
3.3
通讯作者：
Tanaka, Shinya
中科院分区：
文献类型：
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作者：
Kato, Yasutaka;Nishihara, Hiroshi;Tanaka, Shinya
环氧合酶-2 (COX-2) 是前列腺素 (PG) 产生的限速酶，已被证明对某些类型的癌症（包括脑肿瘤）具有致瘤活性。我们评估了脑膜瘤中 COX-2 的表达，脑膜瘤是成人最常见的颅内肿瘤之一，占颅内肿瘤的 24-30%。我们对76例脑膜瘤进行了COX-2免疫染色，其中低级别脑膜瘤44例（WHO I级）和高级别脑膜瘤32例（II级29例，III级3例），并根据染色强度和肿瘤细胞比例评估COX-2表达水平。脑膜瘤细胞中COX-2的表达水平与WHO分级显着相关（P=0.0153）。此外，在所有76例脑膜瘤中，COX-2表达与MIB-1标记指数显着相关（P = 0.0075），表明COX-2在脑膜瘤进展中促进肿瘤进展。我们的结果可能表明非甾体抗炎药对脑膜瘤的治疗价值，特别是对于增殖升高的患者，调节脑膜瘤细胞中COX-2的致瘤活性。
Tumorigenic activity of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the production of prostaglandins (PGs), has been proved for some types of cancer, including brain tumors. We evaluated expression of COX-2 in meningioma, one of the most common intracranial tumors in adults which accounts for 24-30 % of intracranial tumors. We performed immunostaining for COX-2 in 76 cases of meningioma consisting of 44 cases of low-grade (WHO Grade I) and 32 cases of high-grade (29 cases of Grade II and 3 cases of Grade III) meningioma, and evaluated COX-2 expression levels on the basis of staining intensity and proportion in tumor cells. The expression level of COX-2 in meningioma cells was significantly correlated with WHO grade (P = 0.0153). In addition, COX-2 expression was significantly correlated with MIB-1 labeling index for all 76 cases of meningioma (P = 0.0075), suggesting tumor promotion by COX-2 in meningioma progression. Our results may indicate the therapeutic value of non-steroidal anti-inflammatory drugs against meningioma, especially for patients with elevated proliferation, to regulate the tumorigenic activity of COX-2 in meningioma cells.