Epstein-Barr virus in pediatric multiple sclerosis
Epstein-Barr virus in pediatric multiple sclerosis
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DOI：
10.1001/jama.291.15.1875
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发表时间：
2004-04-21
影响因子：
120.7
通讯作者：
Banwell, B
中科院分区：
文献类型：
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作者：
Alotaibi, S;Kennedy, J;Banwell, B
背景感染常见病毒，特别是爱泼斯坦-巴尔病毒(EBV)，已被认为有助于多发性硬化症(MS)的病理生物学。儿科多发性硬化症的病毒学研究尚未见报道。目的评估多发性硬化症儿童EBV或其他常见病毒的血清阳性率是否高于其年龄匹配的健康同龄人。设计、设置和患者病例对照研究从1994年3月至2003年2月收集的30例儿童多发性硬化症患者、90例急诊科对照按出生年份与多发性硬化症患者3：1匹配，以及53名健康对照儿童。主要结果分析存档的血清样本中是否存在针对EBV病毒衣壳抗原、核抗原和早期抗原、巨细胞病毒、细小病毒B19、疱疹病毒、单纯疱疹病毒、结果83%的儿科MS患者有EBV远程感染的血清学证据，急诊科和健康对照组分别为42%和42%(P
Context Infection with common viruses, particularly Epstein-Barr virus (EBV), has been postulated to contribute to the pathobiology of multiple sclerosis (MS). Detailed virological studies in pediatric MS have not been previously reported.Objective To evaluate whether children with MS are more likely to be seropositive for EBV or other common viruses than their healthy age-matched peers.Design, Setting, and Patients Case-control study of viral samples collected from March 1994 to February 2003 from 30 pediatric MS patients, 90 emergency department controls matched 3:1 with the MS patients by year of birth, and 53 healthy control children.Main Outcome Measures Archived serum samples were analyzed for the presence of IgG antibodies directed against EBV viral capsid antigens, nuclear antigens, and early antigens, cytomegalovirus, parvovirus B19, herpes simplex virus, and varicella zoster.Results Serological evidence for remote EBV infection was present in 83% of pediatric MS patients compared with 42% of emergency department and healthy controls (P