Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation.
Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation.
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DOI：
10.4110/in.2014.14.6.277
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发表时间：
2014-12
期刊：
影响因子：
6
通讯作者：
Kim M
中科院分区：
文献类型：
--
作者：
Kim CH;Park J;Kim M
T细胞是调节适应性免疫和免疫耐受的核心参与者。在外周中，T细胞分化成熟和效应子功能由许多因素调节。各种因素如抗原、共刺激信号和细胞因子调节T细胞分化为功能特化的效应和调节T细胞。其他因素如营养素、微量营养素、核激素和微生物产物为T细胞分化提供了重要的环境线索。越来越多的证据表明，微生物代谢产物短链脂肪酸（SCFAs）对T细胞具有深远的影响，并直接或间接地调节其分化。我们回顾了我们对SCFA在调节外周T细胞活性中的功能的理解的现状，并讨论了它们对组织炎症的影响。
T cells are central players in the regulation of adaptive immunity and immune tolerance. In the periphery, T cell differentiation for maturation and effector function is regulated by a number of factors. Various factors such as antigens, co-stimulation signals, and cytokines regulate T cell differentiation into functionally specialized effector and regulatory T cells. Other factors such as nutrients, micronutrients, nuclear hormones and microbial products provide important environmental cues for T cell differentiation. A mounting body of evidence indicates that the microbial metabolites short-chain fatty acids (SCFAs) have profound effects on T cells and directly and indirectly regulate their differentiation. We review the current status of our understanding of SCFA functions in regulation of peripheral T cell activity and discuss their impact on tissue inflammation.