Ischemia-modified albumin in acute stroke
Ischemia-modified albumin in acute stroke
复制标题
DOI：
10.1159/000097644
复制
发表时间：
2007-01-01
影响因子：
2.9
通讯作者：
Amarenco, Pierre
中科院分区：
文献类型：
--
作者：
Abboud, Halim;Labreuche, Julien;Amarenco, Pierre
背景：缺血修饰白蛋白（IMA）是一种新的缺血生物学标志物。以前的研究发现心肌缺血后血清IMA水平升高，但没有研究调查中风改变IMA血液水平的可能性。材料与方法：我们研究了118例在急性神经功能缺损发作后3小时内出现的连续患者[ 84例脑梗死（BI），18例脑出血（ICH）和16例持续不到1小时的短暂性脑缺血发作或癫痫发作]。所有患者在初次就诊时均采集血清样本，仅在卒中患者6、12和24 h时重复采集。通过白蛋白-钴结合试验（Ischemia Technologies，Denver，科洛，USA）。结果如下：BI和ICH患者的初始中位IMA（bootstrap 95%置信区间，CI）分别为83 U/ml（79-86）和86 U/ml（75-90）（p = 0.76），其他患者为73 U/ml（58-79）（与BI相比p = 0.003，与ICH相比p = 0.017）。基线IMA水平与美国国立卫生研究院卒中量表相关[斯皮尔曼相关系数：BI为0.34（p = 0.002），ICH为0.61（p = 0.008）]。在最初的24小时内，BI患者的IMA水平升高（中位数，9.1%; bootstrap 95% CI，5.2-11.5），而ICH患者未观察到变化（中位数，1.2%; bootstrap 95% CI，-7.8至6.8）。结论：IMA可作为急性脑卒中早期诊断的生物标志物。IMA在急性脑卒中早期诊断中的作用有待进一步研究。版权所有（c）2007 S. Karger AG，巴塞尔。
Background: Ischemia-modified albumin (IMA) is a new biological marker of ischemia. Previous studies have found increased serum IMA levels after myocardial ischemia, but no study has investigated the possibility that stroke modifies IMA blood levels. Materials and Methods: We studied 118 consecutive patients presenting within 3 h of the onset of an acute neurological deficit [ 84 brain infarctions (BI), 18 brain hemorrhages (ICH) and 16 transient ischemic attacks lasting less than 1 h or epileptic seizures]. Serum samples were obtained for all patients at initial presentation and repeated only in patients with stroke at 6, 12 and 24 h. IMA was measured by the albumin-cobalt-binding test ( Ischemia Technologies, Denver, Colo., USA). Results: The initial median IMA (bootstrap 95% confidence interval, CI) was 83 U/ml (79-86) and 86 U/ml (75-90) in patients with BI and ICH, respectively ( p = 0.76), and was 73 U/ml (58-79) in others ( p = 0.003 compared with BI, and p = 0.017 with ICH). Baseline IMA levels correlated with the National Institutes of Health Stroke Scale [ Spearman correlation coefficient: 0.34 (p = 0.002) in BI, 0.61 (p = 0.008) in ICH]. During the first 24 h, IMA levels increased in BI patients (median, 9.1%; bootstrap 95% CI, 5.2-11.5), whereas no change was observed in ICH patients ( median, 1.2%; bootstrap 95% CI, -7.8 to 6.8). Conclusions: IMA blood levels may be a biomarker for early identification of acute stroke. Further studies are required to investigate the role of IMA in the early detection of acute stroke. Copyright (c) 2007 S. Karger AG, Basel.