Characterization of polymeric nanoparticles for treatment of partial injury to the central nervous system.
Characterization of polymeric nanoparticles for treatment of partial injury to the central nervous system.
复制标题
用于治疗中枢神经系统部分损伤的聚合物纳米颗粒的表征。
DOI：
10.1016/j.dib.2016.02.019
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发表时间：
2016
期刊：
影响因子：
1.2
通讯作者：
Fitzgerald,Melinda
中科院分区：
文献类型：
--
作者：
Lozić,Ivan;Hartz,RichardV;Bartlett,CaroleA;Shaw,JeremyA;Archer,Michael;Naidu,PriyaSR;Smith,NicoleM;Dunlop,SarahA;Iyer,KSwaminathan;Kilburn,MattR;Fitzgerald,Melinda
在将纳米颗粒用于治疗应用之前，有必要全面研究纳米颗粒的体外和体内效应。在相关的研究文章[1]中，我们产生了带有抗体的多模式聚合物纳米颗粒，旨在向星形胶质细胞输送抗氧化剂。在这里，我们提供了更多的数据，展示了纳米颗粒制剂对体外永生化Müler细胞系中氧化应激指标的影响。我们提供了使用纳米级二次离子质谱仪(NanoSIMS)来鉴定散装干燥NP中的特定离子的数据。NanoSIMS还被用来显示视神经部分横断后的视神经维度中的40Ca微区。相关文章[1]描述了利用NanoSIMS对用不同纳米颗粒制剂处理的动物视神经中的40Ca微区进行定量，并对结果进行了进一步的解释和讨论。
Before using nanoparticles for therapeutic applications, it is necessary to comprehensively investigate nanoparticle effects, bothin vitroandin vivo. In the associated research article [1] we generate multimodal polymeric nanoparticles functionalized with an antibody, that are designed to deliver an anti-oxidant to astrocytes. Here we provide additional data demonstrating the effects of the nanoparticle preparations on an indicator of oxidative stress in an immortalized Müller cell linein vitro. We provide data demonstrating the use of nanoscale secondary ion mass spectroscopy (NanoSIMS) to identify specific ions in bulk dried NP. NanoSIMS is also used to visualize40Ca microdomains in thezdimension of optic nerve that has been subjected to a partial optic nerve transection. The associated article [1] describes the use of NanoSIMS to quantify40Ca microdomains in optic nerve from animals treated with various nanoparticle preparations and provides further interpretation and discussion of the findings.