Ride the wavelet: A multiscale analysis of genomic contexts flanking small insertions and deletions
Ride the wavelet: A multiscale analysis of genomic contexts flanking small insertions and deletions
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DOI：
10.1101/gr.088922.108
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发表时间：
2009-07-01
期刊：
影响因子：
7
通讯作者：
Makova, Kateryna D.
中科院分区：
文献类型：
--
作者：
Kvikstad, Erika M.;Chiaromonte, Francesca;Makova, Kateryna D.
最近的研究表明，插入和缺失（indels）在它们的形成比以前假设的更不同。仍然令人费解的是，局部DNA序列背景如何促成这些差异。为了研究各种分子机制对indel形成的相对影响，我们分析了人类基因组非蛋白质或RNA编码非重复（NCNR）部分中indel的序列背景。我们认为小（
Recent studies have revealed that insertions and deletions (indels) are more different in their formation than previously assumed. What remains enigmatic is how the local DNA sequence context contributes to these differences. To investigate the relative impact of various molecular mechanisms to indel formation, we analyzed sequence contexts of indels in the non protein- or RNA-coding, nonrepetitive (NCNR) portion of the human genome. We considered small (