Infusion timing and sleep habits of adults receiving home parenteral and enteral nutrition: A patient-oriented survey study.
Infusion timing and sleep habits of adults receiving home parenteral and enteral nutrition: A patient-oriented survey study.
复制标题
接受家庭肠外和肠内营养的成人的输注时间和睡眠习惯：一项以患者为导向的调查研究。
DOI：
10.1002/jpen.2446
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Winkler,MarionF
中科院分区：
文献类型：
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作者：
Dashti,HassanS;Rhyner,JordanJ;Mogensen,KrisM;Godbole,Meghna;Saxena,Richa;Compher,Charlene;Winkler,MarionF
时间营养是一个新兴领域，研究营养摄入时间对人体生理和疾病病理的影响。当接受家庭营养支持的患者常规使用家庭肠外营养（HPN）和/或家庭肠内营养（HEN）时，这在很大程度上仍然是未知的。方法本描述性研究收集了一项以患者为导向的调查数据，该调查旨在评估美国接受HPN和HEN的患者的输注时间和睡眠习惯。结果共纳入100例患者。患者平均年龄44.1岁，81%为女性。在73例HPN支持患者和27例HEN支持患者中，分别有86%和44%的患者报告过夜输注。HPN开始和结束过夜输液的中位时间分别为2100（四分位间距[IQR] = 1900-2200）和0800（四分位间距[IQR] = 0700-1000）， HEN开始和结束过夜输液的中位时间分别为2000 （IQR = 1845-2137）和0845 （IQR = 0723-1000）。HPN和HEN分别在睡前2.0 h （IQR = 1.1 ~ 3.0）和2.0 h （IQR = 0.6 ~ 3.3）开始过夜输注，HPN和HEN分别在醒来后12.9 min （IQR = - 21.3 ~ 29.1）和30.0 min （IQR = - 17.1 ~ 79.3）停止过夜输注。与连续输注或白天输注的患者相比，夜间输注的患者因营养支持或排尿而导致的睡眠中断最为常见。结论一项关注营养新维度和医学相关维度的调查研究发现，大多数HPN依赖和HEN依赖患者在夜间睡眠时接受输注。我们的研究结果表明，夜间输液与睡眠同时进行可能会导致睡眠和昼夜节律紊乱。
BackgroundThe emerging field of chrononutrition investigates the effects of the timing of nutritional intake on human physiology and disease pathology. It remains largely unknown when patients receiving home nutrition support routinely administer home parenteral nutrition (HPN) and/or home enteral nutrition (HEN).MethodsThe present descriptive study included data collected from a patient‐oriented survey designed to assess the timing of infusions and sleep habits of patients receiving HPN and HEN in the United States.ResultsA total of 100 patients were included. Patients had a mean age of 44.1 years and 81% were female. Among 73 patients supported with HPN and 27 patients supported with HEN, 86% and 44% reported overnight infusions, respectively. The median start and end times of overnight infusions were 2100 (interquartile range [IQR] = 1900–2200) and 0800 (IQR = 0700–1000), respectively, for HPN and 2000 (IQR = 1845–2137) and 0845 (IQR = 0723–1000), respectively, for HEN. Overnight infusions started 2.0 h (IQR = 1.1–3.0) and 2.0 h (IQR = 0.6–3.3) before bedtime for HPN and HEN, respectively, and stopped 12.9 min (IQR = −21.3 to 29.1) and 30.0 min (IQR = −17.1 to 79.3) after wake time for HPN and HEN, respectively. Sleep disruption because of nutrition support or urination was most common among patients receiving infusions overnight compared with those receiving infusions continuously or during the daytime.ConclusionsOur survey study focusing on a novel and medically relevant dimension of nutrition found that most HPN‐dependent and HEN‐dependent patients receive infusions overnight while asleep. Our findings suggest that overnight infusions coinciding with sleep may result in sleep and circadian disruption.