National surveillance of nosocomial blood stream infection due to species of Candida other than Candida albicans:: Frequency of occurrence and antifungal susceptibility in the SCOPE program
National surveillance of nosocomial blood stream infection due to species of Candida other than Candida albicans:: Frequency of occurrence and antifungal susceptibility in the SCOPE program
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DOI：
10.1016/s0732-8893(97)00192-2
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发表时间：
1998-02-01
影响因子：
2.9
通讯作者：
Wenzel, RP
中科院分区：
文献类型：
--
作者：
Pfaller, MA;Jones, RN;Wenzel, RP
1995年4月至1996年6月期间，美国开展了一项全国医院血流感染监测计划，结果显示念珠菌是院内血流感染的第四大致病原因，占所有感染的8%。379例念珠菌感染中有48%是由白色念珠菌以外的物种引起的。非c的阶序。白色念珠菌种类为：光秃念珠菌（20%）、热带念珠菌（11%）、拟裂念珠菌（8%）、克氏念珠菌（5%）、其他念珠菌（4%）。不同地理区域物种分布不同，非c。白念珠菌以东北（54%）和东南（53%）地区为主，白念珠菌以西北（60%）和西南（70%）地区为主。体外敏感性研究表明95%的Man-C。白色念珠菌对5-氟胞嘧啶敏感，对氟康唑和伊曲康唑敏感的分别为84%和75%。对伊曲康唑的易感性存在地理差异，而对其他药物的易感性无差异。西北和东南地区对伊曲康唑的耐药率（29-30%）高于东北和西南地区（17-18%）。分子流行病学研究显示可能的医院传播（福尔医疗中心）。继续监测非c病毒的存在。建议住院患者中有白色念珠菌。(C) 1998爱思唯尔科学有限公司
A national surveillance program of nosocomial blood stream infections (BSI) in the USA between April 1995 and June 1996 revealed that Candida was the fourth lending cause of nosocomial BSI, accounting for 8% of all infections. Forty-eight percent of 379 episodes of candidemia were due to species other than Candida albicans. The rank order of non-C. albicans species was C. glabrata (20%) > C. tropicalis (11%) > C. parapsilosis (8%) > C. krusei (5%) > other Candida spp. (4%). The species distribution varied according to geographic region, with non-C. albicans species predominating in the Northeast (54%) and Southeast (53%) regions, and C. albicans predominating in the Northwest (60%) and Southwest (70%) regions. In vitro susceptibility studies demonstrated that 95% of Man-C. albicans isolates were susceptible to 5-fluorocytosine, and 84% and 75% were susceptible to fluconazole and itraconazole, respectively. Geographic variation in susceptibility to itraconazole, but not other agents, was observed. Isolates from the Northwest and Southeast regions were more frequently resistant to itraconazole (29-30%) than those from the Northeast and Southwest regions (17-18%). Molecular epidemiologic studies revealed possible nosocomial transmission (Foe medical centers). Continued surveillance for the presence of non-C. albicans species among hospitalized patients is recommended. (C) 1998 Elsevier Science Inc.