Associations of fat mass and fat distribution with bone mineral density in pre- and postmenopausal Chinese women
Associations of fat mass and fat distribution with bone mineral density in pre- and postmenopausal Chinese women
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DOI：
10.1007/s00198-010-1210-9
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Zhu, S.
中科院分区：
文献类型：
--
作者：
Fu, X.;Ma, X.;Zhu, S.
脂肪量（FM）与骨密度（BMD）密切相关。然而，在绝经前后妇女中FM和脂肪分布与BMD的关系仍然知之甚少。绝经后男性体脂含量与骨密度呈负相关，体脂含量与骨密度密切相关。然而，尚不清楚FM和中心脂肪分布是否与绝经前和绝经后妇女的BMD有不同的关联。本研究对267例绝经前和267例绝经后18 ~ 79岁妇女的骨密度（BMD）进行了分析，探讨了FM和脂肪分布与BMD的关系。采用双能X线骨密度仪测量瘦体重（LM）、FM、体脂百分比（%BF）、男性FM、女性FM以及总和局部BMD。脂肪分布通过android与gynoid FM比率（AOI）评估。多元回归分析显示绝经后妇女的FM、%BF、android FM和AOI显著高于绝经后妇女，而总BMD和局部BMD显著低于绝经后妇女（所有NEuro均< 0.01）。在绝经前妇女中，FM与总BMD和局部BMD呈正相关（所有NEuro < 0.05）。AOI与BMD无明显相关性。在绝经后妇女中，FM与总BMD和局部BMD显著相关，甚至额外校正LM（所有NEuro < 0.01）。AOI与全身、头部、手臂和腿部BMD呈显著负相关（所有NEuro < 0.05）。当用%BF代替FM时，结果保持不变。在绝经前后的中国妇女中，FM和脂肪分布与BMD有不同的关联。中心体脂肪增加与BMD呈负相关。我们的研究结果可能对通过减少集中脂肪沉积来预防绝经期相关的骨质疏松症具有重要意义。
Fat mass (FM) is closely related to bone mineral density (BMD). However, the associations of FM and fat distribution with BMD in pre- and postmenopausal women are still poorly understood. The present study showed android fat mass accumulation after menopause had a negative association with BMD.FM is closely related to BMD. However, it is unknown whether FM and central fat distribution have different associations with BMD in pre- and postmenopausal women. The study aims to investigate the associations of FM and fat distribution with BMD in pre- and postmenopausal Chinese women.Two hundred sixty premenopausal and 267 postmenopausal women aged 18 to 79 years were analyzed. Lean mass (LM), FM, percent body fat (%BF), android FM, gynoid FM, and total and regional BMD were measured using dual-energy X-ray absorptiometry. Fat distribution was assessed by android to gynoid FM ratio (AOI). Multiple regression analysis was performed to examine the associations of BMD with FM, LM, and AOI.FM, %BF, android FM, and AOI were significantly higher, whereas total and regional BMD were significantly lower in postmenopausal women (all NEuro < 0.01). In premenopausal women, FM was positively associated with total and regional BMD (all NEuro < 0.05). AOI had no significant association with BMD. In postmenopausal women, FM was significantly associated with total and regional BMD even additionally adjusting for LM (all NEuro < 0.01). AOI had significantly negative association with total, head, arm, and leg BMD (all NEuro < 0.05). The results remained unchanged when replacing FM with %BF.There were different associations of FM and fat distribution with BMD in pre- and postmenopausal Chinese women. Increased central body fat had a negative association with BMD. Our findings may have significant implications in the prevention of menopause-related osteoporosis through reducing centralized fat deposition.