NADPH oxidase (CYBA) and FcγR polymorphisms as risk factors for aggressive periodontitis:: A case-control association study
NADPH oxidase (CYBA) and FcγR polymorphisms as risk factors for aggressive periodontitis:: A case-control association study
复制标题
DOI：
10.1111/j.1600-051x.2006.00952.x
复制
发表时间：
2006-08-01
影响因子：
6.7
通讯作者：
Griffiths, G. S.
中科院分区：
文献类型：
--
作者：
Nibali, L.;Parkar, M.;Griffiths, G. S.
简介：据报道，侵袭性牙周炎（AgP）患者的中性粒细胞（PMN）过度活跃，特别是在超氧化物产生方面。影响中性粒细胞功能的基因多态性已被认为是AgP的候选危险因素。本研究的目的是检测影响中性粒细胞功能的特异性基因多态性与AgP.Material和方法：224例确诊为AgP患者和231例健康牙周组织参加了这项研究。从受试者收集血液样品，并以盲法分析p22（phox）（CYBA）NADPH氧化酶、FP、Fc α和Fc γ受体的基因型。在校正混杂因素的多元逻辑回归模型中，C242 T p22（phox）NADPH氧化酶T等位基因与AgP显著相关，并且在所有受试者中观察到这一点[p=0.002，比值比（OR）=1.87，95%置信区间（CI）=1.27-2.83]和白人（p=0.009，OR=2.07，95% CI=1.20-3.59）。结论：C242 T p22（phox）NADPH氧化酶T等位基因和Fc γ R基因多态性可能通过调节中性粒细胞超氧化物的产生而导致AgP的易感性。
Introduction: Neutrophils (PMN) in aggressive periodontitis (AgP) patients have been reported to be hyperactive especially with regards to superoxide production. Polymorphisms in genes influencing PMN function have been proposed as candidate risk factors for AgP. The aim of this study was to test the association of specific gene polymorphisms affecting PMN functions with AgP.Material and Methods: Two hundred and twenty-four patients with confirmed diagnosis of AgP and 231 subjects with healthy periodontium took part in the study. A blood sample was collected from subjects and genotypes for p22(phox) (CYBA) NADPH oxidase, FP, Fc alpha and Fc gamma receptors were analysed in a blind fashion.Results: The C242T p22(phox) NADPH oxidase T allele was significantly associated with AgP in a multiple logistic regression model adjusting for confounders, and this was observed for all subjects [p=0.002, odds ratio (OR)=1.87, 95% confidence interval (CI)=1.27-2.83] and Caucasians (p=0.009, OR=2.07, 95% CI=1.20-3.59). Concomitant presence of C242T p22(phox) NADPH oxidase T allele and Fc gamma RIIIb NA1 homozygosity was associated with the generalized AgP phenotype in Caucasians (p=0.001, OR=30.35, 95% CI=3.81-241.97).Conclusions: C242T p22(phox) NADPH oxidase and Fc gamma R polymorphisms may predispose to AgP through a modulation of neutrophil superoxide production.