Subepithelial hydrostatic pressure may regulate plasma exudation across the mucosa.
Subepithelial hydrostatic pressure may regulate plasma exudation across the mucosa.
复制标题
上皮下静水压可以调节跨粘膜的血浆渗出。
DOI：
10.1159/000235206
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
A. Luts
中科院分区：
文献类型：
--
作者：
C. Persson;I. Erjefält;B. Gustafsson;A. Luts
本研究在豚鼠体外气管导管实验中证明，浆膜静水压力的微小增加可引起显著的浆膜大分子的粘膜交叉。这段话的可逆性和重复性与体内炎症刺激诱导的气道腔内渗出血浆的出现一致。分别诱导和抑制体内血浆渗出的缓激肽、组胺和特布他林对体外通透性无影响。卡巴胆碱，类似于组胺，收缩气管，但没有增加，而是减少了压力诱导的浆膜大分子的腔内进入。有人认为，血浆渗出诱导的静水压力负荷暂时分离上皮细胞，为大量血浆渗出液进入气道腔提供了一条方向选择性和非损伤性的细胞间途径。这种机制将允许强大的血浆蛋白系统在损伤部位的粘膜表面运行，而不会损害粘膜作为腔内溶质的屏障。
This study demonstrated in guinea pig tracheal tubes in vitro that small increases in serosal hydrostatic pressure caused significant mucosal crossing of serosal macromolecules. Reversibility and repeatability of this passage agree with inflammatory stimulus-induced appearance of exuded plasma in airway lumen in vivo. Bradykinin, histamine, and terbutaline, which induce and inhibit, respectively, plasma exudation in vivo, were without effect on the present in vitro permeability. Carbachol, similar to histamine, contracted the trachea, and did not increase, but rather decreased the pressure-induced luminal entry of serosal macromolecules. It is proposed that a plasma-exudation-induced hydrostatic pressure load transiently separates epithelial cells, providing a direction-selective and non-injurious intercellular pathway for passage of bulk plasma exudate into the airway lumen. This mechanism would allow potent plasma protein systems to operate on mucosal surfaces at sites of insults without compromising the mucosa as a barrier to luminal solutes.