CD8+ T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
CD8+ T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
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DOI：
10.1128/jvi.77.1.68-76.2003
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发表时间：
2003-01-01
影响因子：
5.4
通讯作者：
Chisari, FV
中科院分区：
文献类型：
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作者：
Thimme, R;Wieland, S;Chisari, FV
尽管CD4(+)-和CD8(+)-T细胞对乙型肝炎病毒(HBV)的反应被认为对于控制HBV感染至关重要，但每个T细胞亚群作为病毒清除效应器的相对贡献尚不清楚。为了研究这个问题，我们监测了对照、CD4 缺失和 CD8 缺失黑猩猩的 HBV 感染过程。我们的研究结果表明，CD8+细胞是急性HBV感染期间负责病毒清除和疾病发病机制的主要效应细胞，并且表明病毒清除是由CD8+T细胞反应的非溶细胞和溶细胞效应功能介导的。
Although the CD4(+)- and CD8(+)-T-cell responses to the hepatitis B virus (HBV) are thought to be crucial for the control of HBV infection, the relative contribution of each T-cell subset as an effector of viral clearance is not known. To examine this question, we monitored the course of HBV infection in control, CD4-depleted, and CD8-depleted chimpanzees. Our results demonstrate that CD8(+) cells are the main effector cells responsible for viral clearance and disease pathogenesis during acute HBV infection, and they suggest that viral clearance is mediated by both noncytolytic and cytolytic effector functions of the CD8(+)-T-cell response.