HOMING OF A GAMMA-DELTA THYMOCYTE SUBSET WITH HOMOGENEOUS T-CELL RECEPTORS TO MUCOSAL EPITHELIA
HOMING OF A GAMMA-DELTA THYMOCYTE SUBSET WITH HOMOGENEOUS T-CELL RECEPTORS TO MUCOSAL EPITHELIA
复制标题
DOI：
10.1038/343754a0
复制
发表时间：
1990-02-22
期刊：
影响因子：
64.8
通讯作者：
TONEGAWA, S
中科院分区：
文献类型：
--
作者：
ITOHARA, S;FARR, AG;TONEGAWA, S
具有不同t细胞受体（TCR）谱和归巢特性的IN小鼠γδ t细胞群已经被确定。在淋巴器官1 - 3和肠上皮中发现了不同的种群4,5。相比之下，在小鼠皮肤中发现的γδ t细胞是均匀的。它们表达一种由一种特殊的v - γ - 5和一种特殊的V81链组成的TCR，似乎起源于早期胎儿胸腺细胞。我们现在已经系统地分析了许多组织免疫组织化学和TCR基因测序辅助聚合酶链反应。这些研究表明，第二种同质γδ t细胞亚群存在于阴道、子宫和舌头的上皮中，而不是肠和皮肤的上皮中。这个γδ t细胞亚群表达的TCR由相同的Vδ1链组成。表达这种特殊TCR的细胞先前已被证明在胎儿胸腺晚期呈阳性选择7。
IN mice γδ T-cell populations with distinct T-cell receptor (TCR) repertoires and homing properties have been identified. Diversified populations are found in lymphoid organs1–3and intestinal epithelia4,5. By contrast, the γδ T-cells Is that have been found in the murine skin are homogeneous. They express a TCR consisting of one particular Vγ5 and one particular V81 chain5,6and seem to originate from early fetal thymocytes6,7. We have now systematically analysed many tissues by immunohistochemistry and TCR gene sequencing aided by the polymerase chain reaction. These studies revealed a second homogeneous γδ T-cell subset in epithelia not of the intestine and skin, but of the vagina, uterus and tongue. The TCR expressed by this γδ T-cell subset consists of the same Vδ1 chain. Cells that express this particular TCR have previously been shown to be positively selected in the late fetal thymus7.