How does blood regulate cerebral temperatures during hypothermia?
How does blood regulate cerebral temperatures during hypothermia?
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DOI：
10.1038/s41598-018-26063-7
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发表时间：
2018-05-18
影响因子：
4.6
通讯作者：
Valluri, Prashant
中科院分区：
文献类型：
--
作者：
Blowers, Stephen;Marshall, Ian;Valluri, Prashant
脑血流的宏观建模可以帮助确定头部创伤情况下热干预的影响，以减轻组织损伤。这项工作提出了一个生物热模型，使用3D流体多孔域耦合交叉的1D动脉和静脉血管树。该组合血管多孔（VaPor）模型使用从MRI数据中提取的血管系统解决了脑血流和能量方程，包括代谢产生的热量，并使用树生成算法进行扩展。预期逆流流动会增加脑内的热传递，并且使用血管结构或由流动反向常数CR表示的流动反向来实施。当头皮温度降低时，这些方法与以前的模型（0.39摄氏度）相比表现出更大的平均大脑冷却（从0.56摄氏度+/-<0.01摄氏度到0.58摄氏度+/- < 0.01摄氏度）。由于包括逆流冷却效应，与先前模型（0.11摄氏度）相比，观察到核心脑温度的更大降低（从0.29摄氏度+/-<0.01摄氏度到0.45摄氏度+/- < 0.01摄氏度）。VaPor模型还预测，仅使用头皮冷却，新生儿模型的核心区域可以达到低温平均温度（< 36摄氏度）。
Macro-modeling of cerebral blood flow can help determine the impact of thermal intervention during instances of head trauma to mitigate tissue damage. This work presents a bioheat model using a 3D fluid-porous domain coupled with intersecting 1D arterial and venous vessel trees. This combined vascular porous (VaPor) model resolves both cerebral blood flow and energy equations, including heat generated by metabolism, using vasculature extracted from MRI data and is extended using a tree generation algorithm. Counter-current flows are expected to increase thermal transfer within the brain and are enforced using either the vascular structure or flow reversal, represented by a flow reversal constant, CR. These methods exhibit larger average brain cooling (from 0.56 degrees C +/- < 0.01 degrees C to 0.58 degrees C +/- < 0.01 degrees C) compared with previous models (0.39 degrees C) when scalp temperature is reduced. An greater reduction in core brain temperature is observed (from 0.29 degrees C +/- < 0.01 degrees C to 0.45 degrees C +/- < 0.01 degrees C) compared to previous models (0.11 degrees C) due to the inclusion of counter- current cooling effects. The VaPor model also predicts that a hypothermic average temperature (< 36 degrees C) can be reached in core regions of neonatal models using scalp cooling alone.