THE ONTOGENY OF ULTRASONIC VOCALIZATIONS AND OTHER BEHAVIORS IN MALE JIMPY (JP/Y) MICE AND THEIR NORMAL-MALE LITTERMATES
THE ONTOGENY OF ULTRASONIC VOCALIZATIONS AND OTHER BEHAVIORS IN MALE JIMPY (JP/Y) MICE AND THEIR NORMAL-MALE LITTERMATES
复制标题
DOI：
10.1002/dev.420270204
复制
发表时间：
1994-03-01
影响因子：
2.2
通讯作者：
BROWN, RE
中科院分区：
文献类型：
--
作者：
BOLIVAR, VJ;BROWN, RE
Jimpy （jp/Y）雄性小鼠有一种与性别相关的突变，导致整个中枢神经系统的髓鞘发育异常，引起震颤和行为异常。这些老鼠很少能活过30天。由于这种突变的性别联系性质，在同一窝中会出现瘸腿和正常的雄性幼崽。我们通过记录这些小鼠的运动行为，包括轻微的运动，运动和梳理，以及在2-20日龄的2天间隔的超声波发声（uv），来检查这些小鼠的早期行为发展。矮壮的雄性比它们正常的同伴体重要轻，并且在更晚的年龄达到发育的里程碑。从2-8天大的时候，它们产生的紫外线比正常的雄鼠少，之后两组老鼠的紫外线几乎完全停止了。与正常的同伴相比，病鼠花在协调运动活动（运动和梳理）上的时间更少，而花在轻微运动或不活动上的时间更多。在使用的三个行为测量（紫外线产生、轻微运动和不活动）中，差异在发育早期（产后第2天）就很明显，而在其他测量（运动、梳理）上的差异直到发育后期才明显。我们的结果表明，在检查髓磷脂缺乏的功能影响时，使用多种行为测量的重要性。(C) 1994 John Wiley & Sons, Inc。
Jimpy (jp/Y) male mice have a sex-linked mutation which results in dysmyelination throughout the CNS, causing tremors and behavioral abnormalities. These mice rarely live past 30 days of age. Due to the sex-linked nature of this mutation, both jimpy and normal male pups occur within the same litter. We examined the early behavioral development of these mice by recording their motor behaviors, including slight movement, locomotion and grooming, and their ultrasonic vocalizations (UVs) at 2-day intervals from 2-20 days of age. Jimpy males weighed less than their normal littermates and reached developmental milestones at a later age. They produced fewer UVs than their normal male littermates from 2-8 days of age, after which UVs ceased almost completely in both groups of mice. Jimpy mice spent less time engaged in coordinated motor activities (locomotion and grooming) than normal littermates, and more time engaged in slight movement or remaining inactive. On three of the behavioral measures used (UV production, slight movement, and inactivity) differences were evident early in development (Day 2 postpartum), whereas differences on the other measures (locomotion, grooming) were not evident until later in the developmental period. Our results indicate the importance of using multiple behavioral measures when examining the functional effects of myelin deficiency. (C) 1994 John Wiley & Sons, Inc.