Antihypertensive and antioxidant effects of the Graptopetalum paraguayense E. Walther extract in spontaneously hypertensive rats
Antihypertensive and antioxidant effects of the Graptopetalum paraguayense E. Walther extract in spontaneously hypertensive rats
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DOI：
10.1002/jsfa.3774
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发表时间：
2009-12-01
影响因子：
4.1
通讯作者：
Chou, Su-Tze
中科院分区：
文献类型：
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作者：
Chung, Yun-Chin;Chen, Shu-Ju;Chou, Su-Tze
背景：我们前期的体外研究表明，拟风车草50%乙醇提取物对小鼠有较强的抗肿瘤作用。Walther（GE 50）对血管紧张素转换酶（ACE）有抑制作用。结果：GE 50提取物（2.5 g/kg）连续4周灌胃给药，可显著降低自发性高血压大鼠（SHR）的血压，降低血压升高的组织中ACE活性，而对正常血压的Wistar京都大鼠（WKY）无明显影响。对于SHR，GE 50提取物增加了血浆中的总抗氧化状态，并降低了所有测试组织中的丙二醛水平。此外，GE 50提取物增加脑组织中的α-生育酚和谷胱甘肽水平，心脏中的谷胱甘肽过氧化物酶和过氧化氢酶活性，以及肝组织中的过氧化氢酶活性。结论：GE 50对高血压恢复期大鼠具有抗氧化和ACE抑制作用。(C)2009年化学工业协会
BACKGROUND: Our previous in vitro study showed that 50% ethanolic extract of Graptopetalum paraguayense E. Walther (GE50) exhibited an inhibitory effect on angiotensin I converting enzyme (ACE). This study was aimed at evaluating the antihypertensive and antioxidant effects of GE50 extract on spontaneously hypertensive rats (SHR).RESULTS: Daily oral administration of GE50 extract (2.5 g kg(-1) body weight) for 4 weeks exhibited a significant decrease in blood pressure as well as ACE activity of tested tissues in SHR rats, while no significant change was found in normotensive Wistar Kyoto rats (WKY). For SHR, GE50 extract increased the total antioxidant status in the plasma and decreased malondialdehyde levels in all tested tissues. Furthermore, GE50 extract increased alpha-tocopherol and glutathione levels in brain tissue, glutathione peroxidase and catalase activities in heart, as well as catalase activity in liver tissue. In WKY rats, GE50 extract only increased ascorbic acid level in liver tissue.CONCLUSION: The present study demonstrated that GE50 might serve as an antioxidant and an ACE inhibitor in convalescence from hypertension in rats. (C) 2009 Society of Chemical Industry