Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity
Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: differential effects on selectivity, impulsivity and compulsivity
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DOI：
10.1016/j.bbr.2003.09.020
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发表时间：
2003-11-30
影响因子：
2.7
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Chudasama, Y;Passetti, F;Robbins, TW
越来越明显的是，额叶皮层的多种功能，如抑制控制和执行注意，可能是由其功能独特和相互作用的子区域维持的，但可分离执行过程的精确定位已被证明是困难和有争议的。在本系列研究中，我们研究了大鼠双侧新皮层不同区域的兴奋毒性病变在5选择系列反应时间任务中的行为影响。虽然前扣带背皮层（ACC）的损伤会损害任务的表现，表现为辨别准确性的降低，但额叶皮层不同腹侧区域的损伤显示出控制抑制措施的选择性缺陷。具体而言，边缘下病变产生的过早反应增加，并伴有快速反应潜伏期。相比之下，眶额损伤表现出持续性倾向，特别是当试验间隔时间长且不可预测时，这种挑战通常会促进过早反应。啮齿动物额叶皮质背侧和腹侧损伤后的这些不同行为影响表明，额叶皮质在多种执行机制中是完整的，这些执行机制独立而互补地工作，从而优化了表现。此外，这些数据为啮齿动物额叶皮层的功能组织提供了新的见解，特别强调了功能的定位。(C) 2003 Elsevier B.V.版权所有
It is becoming increasingly apparent that multiple functions of the frontal cortex such as inhibitory control and executive attention are likely sustained by its functionally distinct and interacting sub-regions but the precise localization of dissociable executive processes has proved difficult and controversial. In the present series of studies, we investigated the behavioural effects of bilateral excitotoxic lesions of different regions of the rat neocortex in the 5-choice serial reaction time task. Whereas lesions of the dorsal anterior cingulate cortex (ACC) impaired performance of the task as revealed by a reduction in discriminative accuracy, lesions made to distinct ventral regions of the frontal cortex showed selective deficits in inhibitory measures of control. Specifically, the infralimbic lesion produced increases in premature responding that was accompanied by fast response latencies. By comparison, the orbitofrontal lesion showed perseverative tendencies particularly when the inter-trial interval was made long and unpredictable, a challenge that would normally promote premature responding instead. These different behavioural effects following dorsal and ventral lesions of the rodent frontal cortex signifies the integrity of the frontal cortex in multiple executive mechanisms that work independently and complementarily by which performance is optimized. Furthermore, these data provide new insights into the functional organization of the rodent frontal cortex with a particular emphasis on localization of function. (C) 2003 Elsevier B.V. All rights reserved.