From development to diseases: The role of 5hmC in brain
From development to diseases: The role of 5hmC in brain
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从发育到疾病：5hmC 在大脑中的作用。
DOI：
10.1016/j.ygeno.2014.08.021
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发表时间：
2014-11-01
期刊：
影响因子：
4.4
通讯作者：
Li, Xuekun
中科院分区：
文献类型：
--
作者：
Sun, Wenjia;Zang, Liqun;Li, Xuekun
表观遗传调节在多种生物过程中发挥着重要作用。在过去的几年中，DNA去甲基化已被发现在胚胎和出生后的发展。尽管DNA甲基化的一些潜在功能已经被证明，但在揭示5 hmC的作用方面仍然存在许多问题;它是否仅仅作为DNA去甲基化的中间体或作为稳定的表观遗传标记。5-羟甲基胞嘧啶（5 hmC）不仅是DNA去甲基化的中间体，而且是一种稳定的表观遗传标记。本文就5 hmC在脑内的功能及其与神经元活动、神经发育、衰老和神经系统疾病的关系作一综述。(C)2014爱思唯尔公司All rights reserved.
Epigenetic modulations play essential roles in diverse biological processes. During the past several years, DNA demethylation has been discovered in embryonic and postnatal development. Although some potential functions of DNA methylation have been demonstrated already, many questions remain in terms of unveiling the role of 5hmC; whether it serves either merely as an intermediate of DNA demethylation or as a stable epigenetic marker. 5-hydroxymethylcytosine (5hmC) is proved to be not merely serving as an intermediate of DNA demethylation, but also acts as a stable epigenetic marker. This review summarizes the current knowledge of the function of 5hmC in brain with the focus on the neuronal activity, neurodevelopment, aging, and neurological diseases. (C) 2014 Elsevier Inc. All rights reserved.