Comparative analysis of incidence and clinical features of cutaneous malignant melanoma in Crete (Greece) and southern Germany (central Baden-Wurttemberg)
Comparative analysis of incidence and clinical features of cutaneous malignant melanoma in Crete (Greece) and southern Germany (central Baden-Wurttemberg)
复制标题
DOI：
10.1111/j.1365-2133.2006.07163.x
复制
发表时间：
2006-06-01
影响因子：
10.3
通讯作者：
Garbe, C.
中科院分区：
文献类型：
--
作者：
Lasithiotakis, K.;Leiter, U.;Garbe, C.
背景：对暴露于不同环境因素的不同种族人群的皮肤恶性黑色素瘤（CMM）发病率和流行病学特征进行比较分析，对于考虑皮肤恶性黑色素瘤的病因至关重要，但也可用于公共卫生方法来控制该疾病。目的比较希腊和中欧人群（德国巴登-符腾堡州中部）CMM的发病率和临床特征。方法对1999-2002年克里特岛所有医院的慢性骨髓炎病例进行回顾性分析。欧洲标准人口每年每10万居民的年龄标准化发病率是根据克里特岛人口统计数据计算的。将克里特岛的发现与德国南部的发现进行了比较，这些发现由医院为基础的中央恶性黑色素瘤登记处登记，该登记处同样记录了比以人口为基础的癌症登记处通常记录的更多的临床特征。结果克里特岛1999-2002年的平均发病率为男性每10万居民每年4.01例，女性为4.05例，而德国南部男性为10.6例，女性为11.1例。CMMs的临床特征有显著差异，克里特岛的肿瘤厚度明显更高（中位1.4 mm vs德国南部的0.7 mm）。相应地，与德国南部（11%）相比，在克里特岛（29%）观察到的结节性黑色素瘤明显更多。结论克里特岛CMM的发病率，每年每10万居民中约有4例，明显高于先前的估计，迫切需要尽早认识到克里特岛CMM。然而，德国南部的CMM发病率要高得多。
Background Comparative analysis of the incidence rates and epidemiological features of cutaneous malignant melanoma (CMM) between different ethnic groups exposed to varying environmental factors is critical for consideration of the causes of CMM but can also be utilized in a public health approach to control of the disease.Objectives To compare incidence rates and clinical features of CMM in a Greek and a central European population (central Baden-Wurttemberg, Germany).Methods Incident cases of CMM were traced in all hospitals of the island of Crete for the period 1999-2002. Age-standardized incidence rates per 100 000 inhabitants per year for the European Standard Population were calculated based on the Cretan population statistics. A comparison was performed between the Cretan findings and those of southern Germany as registered by the hospital-based Central Malignant Melanoma Registry, which likewise documents more clinical features than normally recorded by population-based cancer registries.Results Mean incidence rates in Crete for 1999-2002 were 4.01 per 100 000 inhabitants per year for males and 4.05 for females as compared with 10.6 for males and 11.1 for females in southern Germany. There were striking differences in the clinical characteristics of CMMs, with significantly higher tumour thickness in Crete (median 1.4 mm vs. 0.7 mm in southern Germany). Correspondingly, significantly more nodular melanomas were observed in Crete (29%) as compared with southern Germany (11%).Conclusions Incidence of CMM in Crete, with about four cases per 100 000 inhabitants per year, is clearly higher than previously estimated, and there is an urgent necessity for earlier recognition of CMM in Crete. However, the incidence of CMM in southern Germany is much higher.