Comparison of posterior capsule opacification in rabbits receiving either mitomycin-C or distilled water for sealed-capsule irrigation during cataract surgery
Comparison of posterior capsule opacification in rabbits receiving either mitomycin-C or distilled water for sealed-capsule irrigation during cataract surgery
复制标题
DOI：
10.1111/j.1442-9071.2007.01588.x
复制
发表时间：
2007-11-01
影响因子：
4
通讯作者：
Joo, Choun-Ki
中科院分区：
文献类型：
--
作者：
Kim, Su-Young;Kim, Jin-Hyung;Joo, Choun-Ki
目的：比较接受白内障手术并在密封囊冲洗（SCI）期间接受丝裂霉素C（MMC）或蒸馏水（DW）的兔的后囊膜混浊（PCO）。方法：将12只家兔24只眼随机分为三组，每组12只。在囊内超声乳化和植入SCI装置后，将平衡盐溶液（BSS）、DW、MMC 0.4 mg/mL注入囊袋内2 min。术后3个月采用POCOman软件评估PCO程度。结果：术后1 d、1周、2周、3周、1个月、3个月观察组与对照组比较，PCO评分差异有统计学意义（P < 0.05）。MMC组PCO评分明显低于DW组（P < 0.05）。结论：MMC对兔眼后囊膜混浊的抑制作用优于DW; SCI装置对兔眼周围组织具有保护作用。
Purpose: To compare posterior capsule opacification (PCO) in rabbits who undergo cataract surgery and receive either mitomycin-C (MMC) or distilled water (DW) during sealed-capsule irrigation (SCI). In addition, we examined the toxicity of DW and MMC.Methods: Twenty-four eyes from 12 rabbits were divided into three groups. Balanced salt solution (BSS), DW, MMC 0.4 mg/mL was injected into the capsular bag for 2 min after endocapsular phacoemulsification and insertion of a SCI device. The degree of PCO was assessed by POCOman software at 3 months post surgery. Central corneal thickness, anterior chamber inflammation were assessed 1 day, 1 week, 2 weeks, 3 weeks, 1 month and 3 months postoperatively.Results: A statistically significant difference in PCO scores was noted between the control and study groups (P < 0.05). The PCO scores of the MMC group were significantly lower than those of the DW group (P < 0.05). The MMC and DW groups did not show significant toxicity compared with the BSS group.Conclusions: MMC is more effective in reducing PCO than DW; the SCI device can protect the surrounding ocular tissue from MMC toxicity in rabbit eyes.