Interaction of vitamin D and retinoid receptors on regulation of gene expression
Interaction of vitamin D and retinoid receptors on regulation of gene expression
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DOI：
10.1159/000053276
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发表时间：
2000-01-01
期刊：
影响因子：
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通讯作者：
Aranda, A
中科院分区：
文献类型：
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作者：
Jimenez-Lara, AM;Aranda, A
维生素D和视黄酸（RA）受体（分别为VDR和RAR）作为异二聚体与类维生素A X受体（RXR）结合至靶基因中的激素反应元件（HRE）。在某些情况下，RA和维生素D可以通过相同的HRE合作刺激转录。然而，VDR/RXR异二聚体以转录非生产性方式结合，并且在某些RA反应元件上没有确定的极性，并且在这些情况下，维生素D抑制对RA的反应。虽然竞争结合DNA可能有助于这种抑制反应，常见的共激活剂的滴定，VDR也似乎参与transrepression。因此，对RA和维生素D的转录应答依赖于不同受体与DNA和辅激活因子之间相互作用的复杂组合模式。版权所有（C）2001 S. Karger AG，巴塞尔。
Vitamin D and retinoic acid (RA) receptors (VDRs and RARs, respectively), bind as heterodimers with the retinoid X receptor (RXR) to hormone response elements (HREs) in target genes. In some cases RA and vitamin D can cooperate to stimulate transcription through the same HRE. However, VDR/RXR heterodimers bind in a transcriptionally unproductive manner and without a defined polarity on certain RA response elements, and under these circumstances vitamin D inhibits the response to RA. Although competition for binding to DNA may contribute to this inhibitory response, titration of common coactivators; by VDR also appears to be involved in transrepression. Therefore, the transcriptional response to RA and vitamin D depends on a complex combinatory pattern of interaction among different receptors wih DNA and coactivators. Copyright (C) 2001 S. Karger AG, Basel.