Basal Forebrain Cholinergic System and Memory
Basal Forebrain Cholinergic System and Memory
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DOI：
10.1007/7854_2016_467
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Boccia, M. M.
中科院分区：
文献类型：
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作者：
Blake, M. G.;Boccia, M. M.
基底前脑胆碱能神经元构成了许多上行和下行通路的中转站。这些胆碱能神经元在引起皮质激活和唤醒中起作用。已经确定的是，它们主要涉及需要提高唤醒水平、注意状态和/或皮层激活的认知过程，其中EEG中具有去兴奋活动。这些胆碱能神经元受到不同神经递质系统的几种传入的调节。在基底前脑神经元的皮质靶内特别重要的是海马皮质。隔-海马通路是构成隔传出神经系统的一条双向通路，它广泛参与了所有的记忆过程。本文综述了基底前脑神经元对学习记忆认知过程的调节作用及其主要的神经递质系统。
Basal forebrain cholinergic neurons constitute a way station for many ascending and descending pathways. These cholinergic neurons have a role in eliciting cortical activation and arousal. It is well established that they are mainly involved in cognitive processes requiring increased levels of arousal, attentive states and/or cortical activation with desynchronized activity in the EEG. These cholinergic neurons are modulated by several afferents of different neurotransmitter systems. Of particular importance within the cortical targets of basal forebrain neurons is the hippocampal cortex. The septohippocampal pathway is a bidirectional pathway constituting the main septal efferent system, which is widely known to be implicated in every memory process investigated. The present work aims to review the main neurotransmitter systems involved in modulating cognitive processes related to learning and memory through modulation of basal forebrain neurons.