Transplantation strategies to promote repair of the injured spinal cord
Transplantation strategies to promote repair of the injured spinal cord
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DOI：
10.1682/jrrd.2003.08.0055
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发表时间：
2003-07-01
影响因子：
--
通讯作者：
Pearse, DD
中科院分区：
文献类型：
--
作者：
Bunge, MB;Pearse, DD
该综述描述了雪旺细胞和嗅鞘胶质细胞联合其他干预的移植结果。采用全横断损伤模型检测雪旺细胞桥与甲基强的松龙、神经营养因子或嗅鞘胶质细胞的结合。用挫伤模型比较雪旺细胞移植和嗅鞘胶质细胞移植，并检测雪旺细胞移植与升高的环磷酸腺苷水平相结合的结果。联合策略比单独细胞移植更有效。再生反应的改善通常包括继发性组织丢失的减少，脑干神经元的轴突再生，移植物中有髓纤维的增加，再生纤维从移植物进入邻近的脊髓，以及运动功能的改善。
This review describes the results of the transplantation of Schwann cells and olfactory ensheathing glia in combination with other interventions. The complete transection injury model was used to test the combination of Schwann cell bridges with methylprednisolone, neurotrophins, or olfactory ensheathing glia. The contusion injury model was used to compare Schwann cell and olfactory ensheathing glia transplantation and to examine the results of combining Schwann cell transplants with elevated levels of cyclic adenosine monophosphate. The combination strategies were more effective than cell transplantation alone. The improved regeneration response usually involved a reduction in secondary tissue loss, axonal regeneration from brainstem neurons, an increase in myelinated fibers in the transplant, the exit of regenerated fibers from the transplant into the contiguous cord, and an improvement in locomotor function.