Decreased proportions of CD4+IL17+/CD4+CD25+CD127-and CD4+IL17+/CD4+CD25+CD127-FoxP3+T cells in children with autoimmune thyroid diseases
Decreased proportions of CD4+IL17+/CD4+CD25+CD127-and CD4+IL17+/CD4+CD25+CD127-FoxP3+T cells in children with autoimmune thyroid diseases
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DOI：
10.1080/08916934.2016.1183654
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发表时间：
2016-08-01
期刊：
影响因子：
3.5
通讯作者：
Kahaly, George J.
中科院分区：
文献类型：
--
作者：
Bossowski, Artur;Moniuszko, Marcin;Kahaly, George J.
Until now, altered balance of Th1 and Th2 immune cells has been postulated to play an important role in the pathogenesis of autoimmune thyroid diseases (AITD). However, recent studies on thyroid diseases have suggested a new role for Th17 cells that have been classified as a new lineage, distinct from Th1, Th2 and Treg cells. Despite wide interest, the role of Th17 cells in the pathogenesis of inflammatory and autoimmune diseases is still debated. The aim of the study was to estimate the proportions of Th17/Treg T cells in peripheral blood from patients with Graves' disease (GD; n=29, mean age 15.4 +/- 5.1 years), Hashimoto's thyroiditis (HT; n=39, mean age 15.2 +/- 4.1 years) and in healthy controls (n=49, mean age 14.8 +/- 3 years). Polychromatic flow cytometry and several fluorochrome-conjugated monoclonal antibodies were applied to delineate Th17 and Treg cells. The analysis of Th17/Treg T cell proportions in peripheral blood from patients with Graves' disease revealed significantly lower ratios of CD4+IL17+/CD4+CD25+CD127-(p
