Blood pressure variability: Its measurement and significance in hypertension
Blood pressure variability: Its measurement and significance in hypertension
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DOI：
10.1007/s11906-006-0051-6
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发表时间：
2006-06-01
影响因子：
5.6
通讯作者：
Valentini, Mariaconsuelo
中科院分区：
文献类型：
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作者：
Parati, Gianfranco;Faini, Andrea;Valentini, Mariaconsuelo
血压（BP）随时间的波动生理上是由环境刺激，遗传因素和心血管控制机制之间的复杂相互作用引起的。动态BP监测技术，特别是提供逐搏BP记录的系统，已经允许详细描述24小时内对总体BP变异性（BPV）有贡献的不同成分，包括短暂和更持续的BP变化。在高血压中，BPV随着BP水平的升高而升高，并且有证据表明其大小与靶器官损害和心血管事件的发生率密切相关，而与绝对BP水平无关。有研究表明，能够提供平稳的24小时BP、控制、降低BPV的药物可能会提供额外的靶器官保护。数学指标，如谷峰比和平滑指数，代表了24小时内降压作用均匀性的有用指标。仍需进一步研究证实，在人类中，可以降低BPV的干预措施也可以降低心血管事件的发生率。
Blood pressure (BP) fluctuations over time physiologically result from the complex interaction between environmental stimulation, genetic factors, and cardiovascular control mechanisms. Ambulatory BP-monitoring techniques, in particular systems providing beat-by-beat BP recording, have allowed a detailed description of the different components contributing to overall BP variability (BPV) over 24 hours, including short-lasting and more sustained BP changes. In hypertension, BPV increases with increasing BP levels, and evidence is available that its magnitude correlates closely with target-organ damage and with the incidence of cardiovascular events, independent of absolute BP levels. It has been suggested that drugs capable of providing smooth 24-hour BP,control, reducing BPV, may confer additional target-organ protection. Math-ematic indices, such as the trough-to-peak ratio and the smoothness index, represent useful measures of the homogeneity of the antihypertensive effect over 24 hours. Further studies are still needed to confirm that, in humans, interventions that can reduce BPV can also reduce the rate of cardiovascular events.