Quantification of tumor uptake of iodized oils and emulsions of iodized oils: Experimental study
Quantification of tumor uptake of iodized oils and emulsions of iodized oils: Experimental study
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DOI：
10.1148/radiology.201.3.8939223
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发表时间：
1996-12-01
期刊：
影响因子：
19.7
通讯作者：
Roche, A
中科院分区：
文献类型：
--
作者：
deBaere, T;Zhang, XW;Roche, A
目的：为了优化碘油在碘油增强诊断计算机断层扫描 (CT) 和碘 131 标记碘油间质放射治疗中的使用，作者量化了将不同配方的碘油注入肝动脉后碘油的分布。 材料和方法：I-125 标记的碘化罂粟籽油乙酯 将两种粘度（碘化油超流体[粘度，0.04 Pa/sec]和碘化油液[粘度，0.17 Pa/sec]）注射（每种的纯形式和三种不同的乳液）到肝脏中带有VX2肿瘤的兔子的肝动脉中。所有兔子均接受 0.1 mL/kg 碘油中 4 MBq/kg 体重的辐射剂量。 4天后处死动物，评估肿瘤、非肿瘤肝脏和肺中的碘油摄取量。结果：纯碘油超流体或液体之间或用每种类型的碘油制成的相同类型乳液之间的摄取量没有统计学上的显着差异。纯碘油超流体和液体的肺摄取量显着高于除小液滴水包油乳液外的任何乳液（范围，3.72-8.14 kBq/g；平均值，5.68 kBq/g）（分别为 19.75 kBq/g +/- 3.25 [平均值标准误差] vs 19.48 kBq/g +/- 6.15） （10.51 kBq/g +/- 1.18）。由碘油超流体或碘油制成的大液滴油包水乳液的肿瘤与非肿瘤肝脏对碘油的摄取比例显着高于任何其他产品（范围，4.07-5.38；平均值，4.49）（分别为10.26 +/- 2.88和9.53 +/- 0.64）。结论：使用大液滴油包水乳液乳液 肝内携带 VX2 肿瘤的兔子经动脉肝注射后，肺部摄取碘油受到限制，肿瘤摄取增加。
PURPOSE: To optimize use of iodized oil for diagnostic computed tomography (CT) enhanced with iodized oil and for interstitial radiation therapy with iodine-131-labeled iodized oil, the authors quantified the distribution of iodized oil after injection of different formulations of iodized oil into the hepatic artery.MATERIALS AND METHODS: I-125-labeled iodinated ethyl ester of poppyseed oil in two viscosities (iodized oil ultrafluid [viscosity, 0.04 Pa/sec] and iodized oil fluid [viscosity, 0.17 Pa/sec]) was injected (pure forms and three different emulsions of each) into the hepatic artery of rabbits bearing VX2 tumors in the liver. All rabbits received a radiation dose of 4 MBq per kilogram of body weight in 0.1 mL/kg iodized oil. Animals were killed 4 days later, and iodized oil uptake was evaluated in the tumor, nontumorous liver, and lung.RESULTS: There were no statistically significant differences in uptake between pure iodized oil ultrafluid or fluid or between the same type of emulsions made with each type of iodized oil. Lung uptake was significantly higher with pure iodized oil ultrafluid and fluid (19.75 kBq/g +/- 3.25 [standard error of the mean] vs 19.48 kBq/g +/- 6.15, respectively) than with any emulsions (range, 3.72-8.14 kBq/g; mean, 5.68 kBq/g) except the small-droplet oil-in-water emulsion (10.51 kBq/g +/- 1.18). The ratio of tumor to nontumorous liver uptake of iodized oil was significantly higher with large-droplet water-in-oil emulsions made of iodized oil ultrafluid or fluid (10.26 +/- 2.88 and 9.53 +/- 0.64, respectively) than with any other product (range, 4.07-5.38; mean, 4.49).CONCLUSION: Use of large-droplet water-in-oil emulsions limited lung uptake and increased tumor uptake of iodized oil after intraarterial hepatic injection in rabbits bearing VX2 tumors in the liver.