Evaluation of cyclodextrin polymer as an additive for furosemide tablet.
Evaluation of cyclodextrin polymer as an additive for furosemide tablet.
复制标题
环糊精聚合物作为呋塞米片添加剂的评价。
DOI：
10.1248/cpb.32.670
复制
发表时间：
1984
影响因子：
1.7
通讯作者：
T. Nagai
中科院分区：
文献类型：
--
作者：
É. Fenyvesi;K. Takayama;J. Szejtli;T. Nagai
研究了环糊精聚合物作为含有呋塞米、环糊精聚合物和微晶纤维素的直接压片的崩解剂的有效性。基于统计设计实验的回归分析可以确定赋形剂用量对各种片剂特性的影响。经过计算机优化，获得了最佳制剂，其具有高溶出速率、足够的溶出稳定性、快速崩解、制备后的高硬度和老化后足够的硬度。
The effectiveness of cyclodextrin polymer as a disintegrating agent for directly compressed tablets containing furosemide, cyclodextrin polymer and microcrystalline cellulose was investigated. Regression analysis based on statistically designed experiments made it possible to determine how various tablet characteristics are affected by the amount of excipients. As a result of computer optimization an optimum formulation was obtained exhibiting high dissolution rate, sufficient dissolution stability, fast disintegration, high hardness immediately after preparation and adequate hardness after ageing.