Metformin as an Anticancer Drug: A Commentary on the Potential TherapeuticStrategy and Underlying Mechanism of Metformin in Gastric Cancer
Metformin as an Anticancer Drug: A Commentary on the Potential TherapeuticStrategy and Underlying Mechanism of Metformin in Gastric Cancer
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DOI：
10.4172/2167-7700.1000202
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发表时间：
2016-05
期刊：
影响因子：
3.3
通讯作者：
Guanzhen Yu
中科院分区：
文献类型：
--
作者：
Guanzhen Yu
Metformin therapy is a burst of interest in cancer chemoprevention and therapeutic strategies. Epidemiological studies based on cohorts with type 2 diabetes revealed that metformin usage was associated with a reduced risk for various cancer, including breast, colorectal, prostate and pancreas cancers. Meanwhile, the efficacy of cancer chemopreventive effect of metformin has achieved positive results in multiple target organs, especially, colon and mammary cancer [6]. However, only few epidemiological evidences supported the positive link between type2 diabetes and an increased risk of gastric malignancies.
