[Side effects analyses in consideration of renal function for S-1-administered patients].
[Side effects analyses in consideration of renal function for S-1-administered patients].
复制标题
[考虑S-1给药患者的肾功能的副作用分析]。
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Tadashi Yasuda
中科院分区：
文献类型：
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作者：
M. Iwai;M. Kimura;T. Yoshimura;Tadashi Yasuda
尽管报告了许多S-1副作用分析，但尚未报告在考虑肾功能（药物剂量的重要指标）的情况下进行副作用分析。因此，我们在考虑肾功能的情况下研究了副作用。受试者为2008年10月至2009年12月在大垣市立医院外科接受S-1给药的163例患者。肌酐清除率低的患者不良反应发生率高、严重。在血小板减少和脱水方面，3组之间观察到显著差异。药师在用药时应充分考虑肾功能的变化，密切用药指导，积极观察病情进展。
Although many analyses of S-1 side effects are reported, there are no reports where the analyses of side effects were performed in consideration of renal function, which is an important index of medication dose. Therefore, we investigated side effects in consideration of renal function. The subjects were 163 patients administered S-1 at the Department of Surgery of Ogaki Municipal Hospital, between October 2008 and December 2009. The frequency and severity of side effects were high and serious in the groupwhose creatinine clearance was low. A significant difference was observed among 3 groups with regard to thrombocytopenia and dehydration. In conclusion, we think that pharmacists must take renal function into consideration when administering medication, to keepclose medicinal guidance, and to actively observe progress.