Impulsivity and sensation seeking in alcohol abusing patients with schizophrenia.
Impulsivity and sensation seeking in alcohol abusing patients with schizophrenia.
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DOI：
10.3389/fpsyt.2010.00135
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发表时间：
2010
影响因子：
4.7
通讯作者：
Krebs MO
中科院分区：
文献类型：
--
作者：
Dervaux A;Laqueille X;Bourdel MC;Olié JP;Krebs MO
目的：一些研究发现，与一般人群一样，精神分裂症患者的高水平冲动和寻求感觉，特别是去抑制与药物滥用有关。然而，还没有研究专门评估酒精滥用或依赖的精神分裂症患者的冲动性和感觉寻求。材料和方法：我们比较了一组终生酒精滥用或依赖的精神分裂症患者（n = 34）和一组终生药物滥用或依赖的精神分裂症患者（n = 66）的冲动性和感觉寻求。采用DSM-III-R障碍综合国际诊断访谈（CIDI）、阳性和阴性综合征量表（PANSS）、Barratt冲动性量表（BIS）、Zuckerman寻求感觉量表（SSS）和身体快感缺失量表（PAS）对患者进行评估。结果：终身酒精滥用或依赖组冲动性和感觉寻求的平均得分高于无药物滥用或依赖组（BIS分别为63.4±18.7比51.3±14.2，方差分析：F = 11.12, p = 0.001； SSS分别为17.6±5.9比13.5±6.7，方差分析：F = 7.45, p = 0.008）。两组间PAS评分差异无统计学意义。结论：冲动或寻求感觉的增加可能是精神分裂症与酒精滥用或依赖之间的联系。
Objective: Some studies have found that high levels of impulsivity and sensation seeking, particularly disinhibition are associated with substance abuse in patients with schizophrenia, as in the general population. However, no study has assessed impulsivity and sensation seeking specifically in schizophrenia patients with alcohol abuse or dependence. Materials and methods: We compared impulsivity and sensation seeking in a group of schizophrenia patients (DSM-III-R criteria) with lifetime alcohol abuse or dependence (n = 34) and in a group without lifetime substance abuse or dependence (n = 66). The patients were assessed using the composite international diagnostic interview (CIDI) for DSM-III-R disorders, the positive and negative syndrome scale (PANSS), the Barratt impulsivity scale (BIS), the Zuckerman seeking sensation scale (SSS), and the physical anhedonia scale (PAS). Results: The mean scores for impulsivity and sensation seeking were higher in the group with lifetime alcohol abuse or dependence than in the group without substance abuse or dependence (BIS: 63.4 ± 18.7 vs 51.3 ± 14.2 respectively, ANOVA: F = 11.12, p = 0.001; SSS: 17.6 ± 5.9 vs 13.5 ± 6.7 respectively, ANOVA: F = 7.45, p = 0.008). There was no significant difference between the two groups on PAS score. Conclusion: Increased impulsivity or sensation seeking may be a link between schizophrenia and alcohol abuse or dependence.